Drukker Lior, Haklai Ziona, Ben-Yair Schlesinger Mor, Bas-Lando Maayan, Gordon Ethel Sherry, Samueloff Arnon, Schimmel Michael S, Grisaru-Granovsky Sorina
Departments of Obstetrics and Gynecology, Shaare Zedek Medical Center, School of Medicine - Hebrew University, Jerusalem, Israel.
Department of Health Information and Computer Services, Ministry of Health, Jerusalem, Israel.
Early Hum Dev. 2018 Jan;116:76-80. doi: 10.1016/j.earlhumdev.2017.11.011. Epub 2017 Nov 29.
Preterm birth at very low birth weight (VLBW, <1500g) has a multitude of consequences that extend to various aspects of adult life. Little is known about the long-term reproductive outcome of VLBW that survive to adulthood.
To evaluate the reproductive outcome of VLBW infants who survive to adulthood (next-generation).
Retrospective cohort.
Infants born at a single tertiary center between the years 1982-1997 who survived to 18years of age (first-generation).
The number and the birth weight of offspring from adults born with VLBW were compared to those of other birth weight groups born in the same epoch: 1500-2499g, 2500-3799g (reference group) and ≥3800g. We calculated the ratio of actual compared to expected number of children in the next-generation for extreme birth weight parents, using the reference group as a control group and adjusting for birth year. Thereafter, we measured whether first-generation VLBW had an increased risk for a VLBW in the next-generation.
After exclusions, we identified first-generation 67,183 births, including 618 (9.2%) VLBW. There were 193 males and 184 female VLBW infants who survived to adulthood. Both female and male first-generation patients from the VLBW group had half the reproductive rate relative for the normal birth weight group. After adjusting for parental age, male and female VLBW survivors had no significant risk for a VLBW neonate in the next-generation, however, the overall number of are small and may limit any conclusion.
VLBW children who reach adulthood may be at a significantly lower reproductive capacity.
极低出生体重（VLBW，<1500g）的早产会产生诸多后果，这些后果会延伸至成年生活的各个方面。对于存活至成年的极低出生体重儿的长期生殖结局，我们了解甚少。
评估存活至成年（下一代）的极低出生体重儿的生殖结局。
回顾性队列研究。
1982年至1997年间在单一三级医疗中心出生且存活至18岁的婴儿（第一代）。
将极低出生体重的成年人生育的后代数量及出生体重，与同一时期出生的其他出生体重组进行比较：1500 - 2499g、2500 - 3799g（参照组）和≥3800g。我们以参照组作为对照组，并根据出生年份进行调整，计算极端出生体重父母的下一代实际子女数与预期子女数的比率。此后，我们测定第一代极低出生体重儿在下一代中出现极低出生体重的风险是否增加。
排除相关病例后，我们确定了第一代的67183例出生病例，其中包括618例（9.2%）极低出生体重儿。有193名男性和184名女性极低出生体重儿存活至成年。极低出生体重组的第一代男性和女性患者的生殖率均为正常出生体重组的一半。在对父母年龄进行调整后，极低出生体重的男性和女性幸存者在下一代中生育极低出生体重新生儿的风险并无显著差异，然而，总体数量较少，可能会限制任何结论的得出。
成年的极低出生体重儿童的生殖能力可能显著较低。
Zotero 插件