在抗菌治疗中使用噬菌体时是否考虑基因转移？
Is Genetic Mobilization Considered When Using Bacteriophages in Antimicrobial Therapy?
作者信息
Rodríguez-Rubio Lorena, Jofre Joan, Muniesa Maite
机构信息
Department of Genetics, Microbiology and Statistics, Faculty of Biology, Av. Diagonal 643, 08028 Barcelona, Spain.
出版信息
Antibiotics (Basel). 2017 Dec 5;6(4):32. doi: 10.3390/antibiotics6040032.
Abstract
The emergence of multi-drug resistant bacteria has undermined our capacity to control bacterial infectious diseases. Measures needed to tackle this problem include controlling the spread of antibiotic resistance, designing new antibiotics, and encouraging the use of alternative therapies. Phage therapy seems to be a feasible alternative to antibiotics, although there are still some concerns and legal issues to overcome before it can be implemented on a large scale. Here we highlight some of those concerns, especially those related to the ability of bacteriophages to transport bacterial DNA and, in particular, antibiotic resistance genes.
摘要
多重耐药细菌的出现削弱了我们控制细菌感染性疾病的能力。解决这一问题所需的措施包括控制抗生素耐药性的传播、设计新的抗生素以及鼓励使用替代疗法。噬菌体疗法似乎是抗生素的一种可行替代方案，尽管在大规模实施之前仍有一些问题和法律问题需要克服。在这里，我们强调其中的一些问题，特别是那些与噬菌体转运细菌DNA，尤其是抗生素耐药基因的能力相关的问题。
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