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[椎体骨折与血管钙化之间的关联]

[ASSOCIATION BETWEEN VERTEBRAL FRACTURES AND VASCULAR CALCIFICATIONS].

作者信息

Piscopo Giovanni, Morrone Luigi

机构信息

UOC Nefrologia, Dialisi e Trapianto, AOU Policlinico, Bari.

UOC Nefrologia e Dialisi, Ospedale SS Annunziata, Taranto.

出版信息

G Ital Nefrol. 2017 Dec 5;34(Nov-Dec):2017-vol6.

Abstract

Several cross-sectional and prospective studies highlight the existence of an association between bone fractures and abdominal aortic calcifications, especially if particularly severe and independent from confounders such as aging, smoking habits and diabetes. This phenomenon affects not only the general population but also patients with chronic kidney disease in which cortical bone lesions are prevalent. Moreover, bone fractures and aortic calcifications have been proved to be linked to increased cardiovascular morbidity and mortality, both in the general populations and in patients with chronic kidney disease, who notoriously show elevated cardiovascular risks. Therefore, diagnostic investigations about bone fractures and abdominal aortic calcifications, particularly in patients with chronic kidney disease, may represent a useful tool for identification of patients with a higher cardiovascular risk in order to optimize therapies for bone metabolism disorders.

摘要

多项横断面研究和前瞻性研究强调了骨折与腹主动脉钙化之间存在关联,尤其是在钙化特别严重且独立于诸如衰老、吸烟习惯和糖尿病等混杂因素的情况下。这种现象不仅影响普通人群,也影响慢性肾脏病患者,在这类患者中皮质骨病变很普遍。此外,在普通人群和慢性肾脏病患者中,骨折和主动脉钙化均已被证明与心血管发病率和死亡率增加有关,慢性肾脏病患者的心血管风险显著升高。因此,针对骨折和腹主动脉钙化的诊断性检查,尤其是对慢性肾脏病患者而言,可能是识别心血管风险较高患者的有用工具,以便优化骨代谢紊乱的治疗。

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