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作为一种很有前景的湿态人体体内模拟器的微生理系统(MPS)的技术方面。

Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator.

作者信息

Kanamori Toshiyuki, Sugiura Shinji, Sakai Yasuyuki

机构信息

Drug Assay Device Research Group, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Tokyo, Japan.

Department of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8656, Japan; International Research Center on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo, 153-8505, Japan.

出版信息

Drug Metab Pharmacokinet. 2018 Feb;33(1):40-42. doi: 10.1016/j.dmpk.2017.11.006. Epub 2017 Nov 23.

Abstract

Microphysiological systems (MPS) are currently attracting a lot of interest from pharmaceutical companies worldwide. In the United States and European Union, several large government projects related to MPS have been initiated, and, in Japan, pharmaceutical companies interested in MPS are watching the recent trends and developments in the field. In July 2017, the Japan Agency for Medical Research and Development initiated a research program to develop chip-based MPS. In this review, we examine the technical aspects of commercializing chip-based MPS.

摘要

微生理系统(MPS)目前正吸引着全球制药公司的广泛关注。在美国和欧盟,已经启动了几个与MPS相关的大型政府项目,在日本,对MPS感兴趣的制药公司正在关注该领域的最新趋势和发展。2017年7月,日本医疗研究与开发机构启动了一项开发基于芯片的MPS的研究计划。在本综述中,我们探讨了基于芯片的MPS商业化的技术方面。

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