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A型肉毒杆菌毒素用于治疗短暂性直肠疼痛——成功治疗的病例报告

Use of botulinum A toxin for proctalgia fugax-a case report of successful treatment.

作者信息

Grigoriou Marios, Ioannidis Aristeidis, Kofina Konstantinia, Efthimiadis Christoforos

机构信息

Department of Surgery, Interbalkan Medical Center, Thessaloniki, Greece.

Department of Surgery, Euromedica General Clinic, Thessaloniki, Greece.

出版信息

J Surg Case Rep. 2017 Nov 29;2017(11):rjx236. doi: 10.1093/jscr/rjx236. eCollection 2017 Nov.

Abstract

Proctalgia fugax is considered as intermittent anal pain of unknown etiology; a variety of treatments have been used, without, however, permanent results. Injection of botulinum A toxin is recently suggested as an alternative option. We present the case of a woman presenting proctalgia fugax that was untreatable through other current forms of treatment. After two administrations of botulinum A toxin, 80 units and 100 units each, the patient remained asymptomatic on 8-month follow-up control. Botulinum A toxin injection can reduce internal anal sphincter pressure, leading to relief of symptoms, and seems a promising option with minimal morbidity in cases on proctalgia fugax that does not respond to other current treatments.

摘要

直肠痛性痉挛被认为是病因不明的间歇性肛门疼痛;已经使用了多种治疗方法,但都没有取得永久性的效果。最近有人建议注射A型肉毒杆菌毒素作为一种替代选择。我们报告一例直肠痛性痉挛的女性病例,该病例通过目前其他治疗方式无法治愈。在两次注射A型肉毒杆菌毒素(每次分别为80单位和100单位)后,患者在8个月的随访中一直无症状。注射A型肉毒杆菌毒素可降低肛门内括约肌压力,从而缓解症状,对于其他现有治疗方法无效的直肠痛性痉挛病例,它似乎是一种有前景且发病率极低的选择。

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