体内少突胶质细胞钙瞬变对髓鞘伸长发育的调控。
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo.
机构信息
Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Department of Cell and Developmental Biology, University College London, London, UK.
出版信息
Nat Neurosci. 2018 Jan;21(1):24-28. doi: 10.1038/s41593-017-0031-y. Epub 2017 Dec 11.
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca] in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca] transients and prevented by [Ca] buffering. Sheath elongation occurs ~1 h after [Ca] elevation. Sheath shortening is associated with a low frequency of [Ca] transients but with longer duration [Ca] bursts. Thus, [Ca] controls myelin sheath development.
动作电位如何调节少突胶质细胞的髓鞘形成尚不确定。我们发现，神经元活动会提高体内发育中的少突胶质细胞内的[Ca]，而[Ca]瞬变的高频和[Ca]缓冲则会促进髓鞘伸长，抑制髓鞘伸长。髓鞘伸长发生在[Ca]升高后约 1 小时。髓鞘缩短与[Ca]瞬变的低频相关，但[Ca]爆发的持续时间较长。因此，[Ca]控制着髓鞘的发育。
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