尿α1-微球蛋白水平与非酒精性脂肪性肝病的关系：一项横断面研究。

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study.

机构信息

Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Clinical Medicine, Hangzhou Normal University Qianjiang College, Hangzhou, China.

出版信息

Ann Nutr Metab. 2018;72(1):30-36. doi: 10.1159/000484255. Epub 2017 Dec 12.

DOI:10.1159/000484255

PMID:29232673

Abstract

BACKGROUND

We aimed to explore the association between urinary alpha1-microglobulin (A1M) levels and nonalcoholic fatty liver disease (NAFLD) in a Chinese population.

STUDY

We performed a cross-sectional study among 2,215 Chinese who attended their annual health examination at First Affiliated Hospital, College of Medicine, Zhejiang University. Urinary A1M-creatinine ratio and other clinical and laboratory parameters were measured.

RESULTS

A total of 20.9% of subjects fulfilled the diagnostic criteria of NAFLD. NAFLD subjects had significantly higher urinary A1M-creatinine ratios. These levels were positively associated with NAFLD prevalence. The association between A1M-creatinine ratio and NAFLD was independent of hyperglycemia status. Stepwise regression showed that urinary A1M-creatinine ratio was significantly associated with the risk for NAFLD. Urinary A1M-creatinine ratio was an independent factor predicting advanced fibrosis (FIB-4 ≥1.3) in NAFLD patients.

CONCLUSIONS

Our results showed a significant association between urinary A1M-creatinine ratio and NAFLD.

摘要

背景

本研究旨在探讨中国人群尿α1-微球蛋白（A1M）水平与非酒精性脂肪性肝病（NAFLD）之间的关系。

方法

我们对在浙江大学医学院附属第一医院接受年度体检的 2215 名中国人进行了横断面研究。测量了尿 A1M-肌酐比值和其他临床及实验室参数。

结果

共有 20.9%的受试者符合 NAFLD 的诊断标准。NAFLD 患者的尿 A1M-肌酐比值显著升高。这些水平与 NAFLD 的患病率呈正相关。A1M-肌酐比值与 NAFLD 的相关性独立于高血糖状态。逐步回归显示，尿 A1M-肌酐比值与 NAFLD 的风险显著相关。尿 A1M-肌酐比值是预测 NAFLD 患者发生肝纤维化（FIB-4≥1.3）的独立因素。