间充质干细胞来源的外泌体治疗脑损伤的研究进展
[Research advances in mesenchymal stem cell-derived exosomes in treatment of brain injury].
作者信息
Yue Yan, Qu Yi, Mu De-Zhi
机构信息
Department of Pediatrics, West China Second Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Dec;19(12):1285-1290. doi: 10.7499/j.issn.1008-8830.2017.12.012.
Mesenchymal stem cell (MSC) transplantation is considered one of the most promising therapeutic strategies for the repair of brain injuries and plays an important role in various links of nerve repair. Recent studies have shown that MSC-derived exosomes may dominate the repair of brain injuries and help to promote angiogenesis, regulate immunity, inhibit apoptosis, and repair the nerves, and therefore, they have a great potential in the treatment of brain injuries in neonates. With reference to these studies, this article reviews the mechanism of action of exosomes in the repair of brain injuries and related prospects and challenges, in order to provide new directions for the treatment of brain injuries in neonates with stem cells.
间充质干细胞（MSC）移植被认为是修复脑损伤最有前景的治疗策略之一，在神经修复的各个环节中发挥着重要作用。最近的研究表明，MSC来源的外泌体可能在脑损伤修复中起主导作用，并有助于促进血管生成、调节免疫、抑制细胞凋亡和修复神经，因此，它们在新生儿脑损伤治疗中具有巨大潜力。参照这些研究，本文综述了外泌体在脑损伤修复中的作用机制以及相关的前景和挑战，以便为新生儿干细胞治疗脑损伤提供新的方向。
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