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瘙痒的诊断与治疗。

Diagnosis and treatment of pruritus.

机构信息

Chief Resident at McMaster Family Practice and a final-year resident in the Department of Family Medicine at McMaster University in Hamilton, Ont.

Medical Director of the Phototherapy Education and Research Centre at Women's College Hospital in Toronto, Ont, a dermatologist, and Lecturer for the University of Toronto.

出版信息

Can Fam Physician. 2017 Dec;63(12):918-924.

PMID:29237630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5729138/
Abstract

OBJECTIVE

To describe an approach that allows for a streamlined assessment and accurate differentiation of most patients with itch in primary care and to provide an update on the available nonpharmacologic, topical, and systemic therapies.

SOURCES OF INFORMATION

MEDLINE (Ovid) and PubMed were searched for the key words or Searches were refined for each cause and treatment by adding appropriate key words, and subsequent hand searches of the references of retrieved literature were performed.

MAIN MESSAGE

A good body of evidence from high-quality trials does not exist for treatment of pruritus, and the treatments that do exist are inconsistent in their success. The dominant causes of generalized itch are xerosis and eczema. Most patients will improve with nonpharmacologic therapy including frequent moisturization. If this avenue fails, further investigations are warranted to help guide subsequent treatment with any of the many cause-specific topical and systemic approaches available.

CONCLUSION

Chronic itch can be debilitating for patients. The approach described allows for a streamlined assessment and accurate differentiation of most patients with itch in primary care.

摘要

目的

描述一种方法,以便在初级保健中对大多数瘙痒患者进行简化评估和准确区分,并提供有关非药物、局部和全身治疗方法的最新信息。

信息来源

在 MEDLINE(Ovid)和 PubMed 上搜索关键词[pruritus]或[itch]。通过添加适当的关键词对每种病因和治疗方法进行了搜索细化,并对检索文献的参考文献进行了后续的手工搜索。

主要信息

高质量试验并未提供治疗瘙痒的大量证据,而且现有的治疗方法在疗效上并不一致。全身性瘙痒的主要原因是干燥和湿疹。大多数患者将通过非药物治疗(包括经常保湿)得到改善。如果这条途径失败,则需要进一步调查以帮助指导随后针对许多特定病因的局部和全身治疗方法中的任何一种进行治疗。

结论

慢性瘙痒会使患者身体虚弱。所描述的方法允许在初级保健中对大多数瘙痒患者进行简化评估和准确区分。

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本文引用的文献

1
Sertraline as an Additional Treatment for Cholestatic Pruritus in Children.舍曲林作为儿童胆汁淤积性瘙痒的辅助治疗药物。
J Pediatr Gastroenterol Nutr. 2017 Mar;64(3):431-435. doi: 10.1097/MPG.0000000000001385.
2
DSM-5 Update in Psychodermatology.《精神皮肤病学中的DSM-5更新》
Skin Therapy Lett. 2016 May;21(3):4-7.
3
Gabapentin and pregabalin for the treatment of chronic pruritus.加巴喷丁和普瑞巴林治疗慢性瘙痒。
J Am Acad Dermatol. 2016 Sep;75(3):619-625.e6. doi: 10.1016/j.jaad.2016.02.1237. Epub 2016 May 17.
4
Nocturnal Pruritus: The Battle for a Peaceful Night's Sleep.夜间瘙痒:为安睡而战。
Int J Mol Sci. 2016 Mar 22;17(3):425. doi: 10.3390/ijms17030425.
5
An evidence-based review of systemic treatments for itch.关于瘙痒系统性治疗的循证综述。
Eur J Pain. 2016 Jan;20(1):24-31. doi: 10.1002/ejp.766. Epub 2015 Sep 28.
6
Nalfurafine hydrochloride to treat pruritus: a review.盐酸纳呋拉啡治疗瘙痒症:综述
Clin Cosmet Investig Dermatol. 2015 May 11;8:249-55. doi: 10.2147/CCID.S55942. eCollection 2015.
7
Placebo effects on itch: a meta-analysis of clinical trials of patients with dermatological conditions.安慰剂对瘙痒的影响:皮肤病患者临床试验的荟萃分析。
J Invest Dermatol. 2015 May;135(5):1234-1243. doi: 10.1038/jid.2014.522. Epub 2014 Dec 1.
8
Capsaicin 8% cutaneous patch: a promising treatment for brachioradial pruritus?8%辣椒素皮肤贴片:治疗肱桡肌瘙痒症的一种有前景的疗法?
Br J Dermatol. 2015 Jun;172(6):1669-1671. doi: 10.1111/bjd.13501. Epub 2015 Apr 13.
9
The role of capsaicin in dermatology.辣椒素在皮肤病学中的作用。
Prog Drug Res. 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12.
10
Systemic therapy for atopic dermatitis.特应性皮炎的系统治疗。
Allergy. 2014 Jan;69(1):46-55. doi: 10.1111/all.12339. Epub 2013 Dec 20.