预防类鼻疽和马鼻疽的疫苗
Vaccines for the Prevention of Melioidosis and Glanders.
作者信息
Johnson Monica M, Ainslie Kristy M
机构信息
Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, USA.
出版信息
Curr Trop Med Rep. 2017 Sep;4(3):136-145. doi: 10.1007/s40475-017-0121-7. Epub 2017 Jul 14.
Abstract
PURPOSE OF REVIEW
's and 's high rate of infectivity, limited treatment options, and potential use as biological warfare agents underscore the need for development of effective vaccines against these bacteria. Research efforts focused on vaccines against these bacteria are in pre-clinical stages, with no approved formulations currently on the market.
RECENT FINDINGS
Several live attenuated and subunit vaccine formulations have been evaluated in animal studies, with no reports of significant long term survival after lethal challenge.
SUMMARY
This review encompasses the most current vaccine strategies to prevent and infections while providing insight for successful vaccines moving forward.
摘要
综述目的
[细菌名称1]和[细菌名称2]的高感染率、有限的治疗选择以及作为生物战剂的潜在用途凸显了开发针对这些细菌的有效疫苗的必要性。针对这些细菌的疫苗研发工作正处于临床前阶段，目前市场上尚无获批的制剂。
最新发现
几种减毒活疫苗和亚单位疫苗制剂已在动物研究中进行了评估，但在致死性攻击后尚无显著长期存活的报告。
总结
本综述涵盖了预防[细菌名称1]和[细菌名称2]感染的最新疫苗策略，同时为未来成功研发疫苗提供了见解。
相似文献
1
Vaccines for the Prevention of Melioidosis and Glanders.
Curr Trop Med Rep. 2017 Sep;4(3):136-145. doi: 10.1007/s40475-017-0121-7. Epub 2017 Jul 14.
2
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders.
PLoS One. 2015 Jul 6;10(7):e0132032. doi: 10.1371/journal.pone.0132032. eCollection 2015.
3
Burkholderia vaccines: are we moving forward?
Front Cell Infect Microbiol. 2013 Feb 5;3:5. doi: 10.3389/fcimb.2013.00005. eCollection 2013.
4
Development of Burkholderia mallei and pseudomallei vaccines.
Front Cell Infect Microbiol. 2013 Mar 11;3:10. doi: 10.3389/fcimb.2013.00010. eCollection 2013.
5
Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders.
Vaccine. 2009 Jul 16;27(33):4447-51. doi: 10.1016/j.vaccine.2009.05.040. Epub 2009 May 31.
6
Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis.
PLoS Negl Trop Dis. 2019 Jul 15;13(7):e0007578. doi: 10.1371/journal.pntd.0007578. eCollection 2019 Jul.
7
Burkholderia pseudomallei Δ Δ Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection.
mSphere. 2019 Jan 2;4(1):e00570-18. doi: 10.1128/mSphere.00570-18.
8
Strategies toward vaccines against Burkholderia mallei and Burkholderia pseudomallei.
Expert Rev Vaccines. 2008 Nov;7(9):1357-65. doi: 10.1586/14760584.7.9.1357.
9
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders.
Front Cell Infect Microbiol. 2012 Aug 15;2:108. doi: 10.3389/fcimb.2012.00108. eCollection 2012.
10
Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?
Vaccine. 2017 Oct 20;35(44):5981-5989. doi: 10.1016/j.vaccine.2017.03.022. Epub 2017 Mar 21.
引用本文的文献
1
Glanders Diagnosis in an Asymptomatic Mare from Brazil: Insights from Serology, Microbiological Culture, Mass Spectrometry, and Genome Sequencing.
Pathogens. 2023 Oct 17;12(10):1250. doi: 10.3390/pathogens12101250.
2
Evaluation of two different vaccine platforms for immunization against melioidosis and glanders.
Front Microbiol. 2022 Aug 17;13:965518. doi: 10.3389/fmicb.2022.965518. eCollection 2022.
3
Natural-Product-Based Solutions for Tropical Infectious Diseases.
Clin Microbiol Rev. 2021 Dec 15;34(4):e0034820. doi: 10.1128/CMR.00348-20. Epub 2021 Sep 8.
4
Prediction of Burkholderia pseudomallei DsbA substrates identifies potential virulence factors and vaccine targets.
PLoS One. 2020 Nov 20;15(11):e0241306. doi: 10.1371/journal.pone.0241306. eCollection 2020.
5
A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor.
Virulence. 2020 Dec;11(1):1041-1058. doi: 10.1080/21505594.2020.1806675.
6
Whole genome sequencing analysis of a dexamethasone-degrading Burkholderia strain CQ001.
Medicine (Baltimore). 2019 Aug;98(33):e16749. doi: 10.1097/MD.0000000000016749.
本文引用的文献
1
Acetalated Dextran Microparticulate Vaccine Formulated via Coaxial Electrospray Preserves Toxin Neutralization and Enhances Murine Survival Following Inhalational Bacillus Anthracis Exposure.
Adv Healthc Mater. 2016 Oct;5(20):2617-2627. doi: 10.1002/adhm.201600642. Epub 2016 Sep 5.
2
Degradation of acetalated dextran can be broadly tuned based on cyclic acetal coverage and molecular weight.
Int J Pharm. 2016 Oct 15;512(1):147-157. doi: 10.1016/j.ijpharm.2016.08.031. Epub 2016 Aug 16.
3
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders.
Infect Immun. 2016 Jul 21;84(8):2345-54. doi: 10.1128/IAI.00328-16. Print 2016 Aug.
4
Burkholderia cepacia Complex Vaccines: Where Do We Go from here?
Vaccines (Basel). 2016 Apr 15;4(2):10. doi: 10.3390/vaccines4020010.
5
Identification of an OmpW homologue in Burkholderia pseudomallei, a protective vaccine antigen against melioidosis.
Vaccine. 2016 May 17;34(23):2616-21. doi: 10.1016/j.vaccine.2016.03.088. Epub 2016 Apr 16.
6
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice.
Front Cell Infect Microbiol. 2016 Feb 26;6:21. doi: 10.3389/fcimb.2016.00021. eCollection 2016.
7
Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease.
Vaccine. 2016 Mar 29;34(14):1665-71. doi: 10.1016/j.vaccine.2016.02.038. Epub 2016 Feb 23.
8
Evaluation of a biodegradable microparticulate polymer as a carrier for Burkholderia pseudomallei subunit vaccines in a mouse model of melioidosis.
Int J Pharm. 2015 Nov 30;495(2):849-61. doi: 10.1016/j.ijpharm.2015.09.059. Epub 2015 Sep 28.
9
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders.
PLoS One. 2015 Jul 6;10(7):e0132032. doi: 10.1371/journal.pone.0132032. eCollection 2015.
10
Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development.
PLoS Negl Trop Dis. 2015 Jun 26;9(6):e0003863. doi: 10.1371/journal.pntd.0003863. eCollection 2015.
Zotero 插件