当清晰至关重要时：调节眼表面免疫。
When Clarity Is Crucial: Regulating Ocular Surface Immunity.
机构信息
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; University College London (UCL) Institute of Ophthalmology, University College London, London, UK.
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
出版信息
Trends Immunol. 2018 Apr;39(4):288-301. doi: 10.1016/j.it.2017.11.007. Epub 2017 Dec 14.
Abstract
The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea - blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge.
摘要
眼表面是一个独特的黏膜免疫部位，其解剖学、生理学和免疫学特征协同作用，营造出一种特别耐受的微环境。这些机制对于眼睛的功能至关重要，事实上，角膜炎症过度会导致失明，这一事实就突显了这一点。最近的数据阐明了特定解剖结构成分、免疫细胞和可溶性免疫调节因子在促进眼表面稳态方面的作用。我们重点介绍了这个独特的黏膜屏障的研究趋势，并确定了我们当前知识中的关键空白。
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