O'Connor Michael K, Tran Thuy D, Swanson Tiffinee N, Ellingson Lacey R, Hunt Katie N, Whaley Dana H
Department of Radiology, Charlton 1-225, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
EJNMMI Res. 2017 Dec 19;7(1):100. doi: 10.1186/s13550-017-0351-7.
Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of these systems. The primary objective of this study was to determine if modifications to the design of the imaging table and detector used for a db-PET system would enable improved visualization of breast tissue close to the chest wall. All studies were performed on a commercially available db-PET system (Mammi-PET). A central square section of the imaging table, containing the standard 180-mm circular aperture, was modified such that it could be removed and replaced by thinner sections with a larger aperture. Additional changes were made to the cover plate of the detector array and the patient mattress. A total of 60 patients were studied. After administration of F-18 FDG, 30 patients were imaged with a 220-mm-diameter aperture and the standard aperture, and 30 patients with a 200-mm aperture and the standard aperture. On all scans, the length of breast tissue in the field of view was measured as the greatest extent of tissue from the nipple back to the posterior edge of the breast. Image quality and patient comfort were recorded.
Averaged over both breasts, relative to the standard aperture, the increase in breast length was 12.5 + 7.7 mm with the 220-mm aperture, and 12.3 + 6.5 mm with the 200-mm aperture (p < 0.05 for both apertures). In ~ 5% of cases, the larger apertures resulted in some degradation in image quality due to closer proximity to cardiac/hepatic activity. In 10-20% of cases, movement of the breast tissue was observed as the detector ring was moved to scan the anterior region of the breast. The patient survey indicated no significant difference in the comfort level between the standard aperture and either of the prototype apertures.
Modifications to the image table and system resulted in a significant gain in the volume of breast tissue that could be imaged on the db-PET system and should allow better visualization of lesions close to the chest wall.
距离胸壁不到2厘米的乳腺病变在专用乳腺正电子发射断层显像(db-PET)系统的视野中难以定位。无法检测到此类病变是这些系统的一个重大局限。本研究的主要目的是确定对db-PET系统所用成像台和探测器的设计进行修改是否能改善对靠近胸壁的乳腺组织的可视化。所有研究均在市售的db-PET系统(Mammi-PET)上进行。成像台的中央方形部分,包含标准的180毫米圆形孔径,进行了修改,使其可以拆除并用孔径更大的更薄部分替换。对探测器阵列的盖板和患者床垫也做了其他改动。共研究了60名患者。注射F-18 FDG后,30名患者用直径220毫米的孔径和标准孔径进行成像,30名患者用200毫米的孔径和标准孔径进行成像。在所有扫描中,视野内乳腺组织的长度测量为从乳头到乳腺后缘的最大组织范围。记录图像质量和患者舒适度。
双侧乳房平均而言,相对于标准孔径,220毫米孔径时乳腺长度增加了12.5±7.7毫米,200毫米孔径时增加了12.3±6.5毫米(两种孔径均p<0.05)。在约5%的病例中,较大的孔径由于更靠近心脏/肝脏活动而导致图像质量有所下降。在10%-20%的病例中,当探测器环移动以扫描乳腺前部区域时,观察到乳腺组织有移动。患者调查表明标准孔径与任何一种原型孔径之间的舒适度没有显著差异。
对成像台和系统的修改使db-PET系统上可成像的乳腺组织体积有显著增加,应该能更好地可视化靠近胸壁的病变。