特立帕肽治疗期间长期卧床休息后骨面积骨密度显著降低。
Significant Loss of Areal Bone Mineral Density Following Prolonged Bed Rest During Treatment With Teriparatide.
作者信息
Martin Christopher T, Niewoehner Catherine B, Burmeister Lynn A
机构信息
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455.
出版信息
J Endocr Soc. 2017 Apr 24;1(6):609-614. doi: 10.1210/js.2017-00049. eCollection 2017 Jun 1.
We present of a case of severe osteoporosis with thoracic myelopathy secondary to nontraumatic T8 compression fracture managed nonsurgically with 3.5 months of bed rest. Despite treatment with teriparatide starting at initial presentation, 1-year follow-up dual energy x-ray absorptiometry scan revealed a significantly greater than expected 19% reduction in lumbar spine bone mineral density (BMD) and a 6% reduction in total hip density. Daily alcohol consumption, severe osteoporosis at baseline, and immobilization secondary to transient myelopathy treated with strict bed rest all likely contributed to unexpected BMD findings.
我们报告了一例严重骨质疏松症合并胸椎脊髓病的病例，该脊髓病继发于非创伤性T8压缩性骨折，通过3.5个月的卧床休息进行非手术治疗。尽管在初次就诊时就开始使用特立帕肽进行治疗，但1年随访的双能X线吸收法扫描显示，腰椎骨密度（BMD）下降了19%，显著高于预期，全髋骨密度下降了6%。每日饮酒、基线时的严重骨质疏松症以及因短暂性脊髓病而进行严格卧床休息导致的制动，都可能导致了意外的骨密度检查结果。
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