金黄色葡萄球菌与囊性纤维化患儿支气管扩张症的相关性。
The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis.
机构信息
Telethon Kids Institute, Perth, Australia; Dept. of Respiratory Medicine, Princess Margaret Hospital, Perth, Australia; Dept. of Pediatrics/Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands.
Telethon Kids Institute, Perth, Australia.
出版信息
J Cyst Fibros. 2018 Jul;17(4):462-469. doi: 10.1016/j.jcf.2017.12.002. Epub 2017 Dec 21.
BACKGROUND
Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease.
METHODS
In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5-7years were investigated. Models were adjusted for multiple markers of disease severity at baseline.
RESULTS
De novo S. aureus acquisition at 3-years-old (n/N=12/122) was associated with increased bronchiectasis score at age 5-6years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF at age 5-7years, but not with FEV-%-predicted.
CONCLUSION
De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF in children with CF.
背景
金黄色葡萄球菌（S. aureus）可能与囊性纤维化（CF）肺部疾病的快速进展有关。
方法
在 AREST CF 队列研究中，诊断为 CF 的儿童每年进行支气管镜检查，包括支气管肺泡灌洗和超低剂量胸部计算机断层扫描（CT），直至 6 岁。4 岁起每 3 个月进行一次肺量计检查。研究了学龄前新获得金黄色葡萄球菌与 5-7 岁时 CT 和肺功能的关系。模型根据基线时多种疾病严重程度标志物进行了调整。
结果
3 岁时新获得金黄色葡萄球菌（n/N=12/122）与 5-6 岁时支气管扩张评分增加有关。在调整混杂因素后，这种关联虽然减弱但仍然显著。3 岁时金黄色葡萄球菌与 5-7 岁时的 FEF 显著降低有关，但与 FEV-%-predicted 无关。
结论
3 岁时新获得金黄色葡萄球菌与 CF 儿童后期的支气管扩张和 FEF 有关。
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