现场和临床估计表明，在蚊子中 -mediated 阻断登革热病毒传播潜力。
Field- and clinically derived estimates of -mediated blocking of dengue virus transmission potential in mosquitoes.
机构信息
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, District 5, Ho Chi Minh City, Vietnam;
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia.
出版信息
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):361-366. doi: 10.1073/pnas.1715788115. Epub 2017 Dec 26.
The Mel strain of can reduce the permissiveness of mosquitoes to disseminated arboviral infections. Here, we report that Mel-infected (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The Mel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of Mel introgression for the biocontrol of -born arboviruses.
曼氏隐球菌株能够降低传播性虫媒病毒感染的嗜性。在这里，我们报告称，感染曼氏隐球菌的（胡志明市背景）在直接吸食 141 例登革热病毒血症患者的血液时，其登革病毒（DENV）传播潜力更低，外潜伏期比野生型蚊长。与实验室饲养的蚊相比，野外饲养的感染曼氏隐球菌的蚊对感染登革热病毒血症患者来源的血餐具有更高的相对抵抗力。这是因为野外饲养的野生型蚊比实验室饲养的蚊更容易感染。总的来说，这些与野外和临床相关的发现支持继续仔细野外测试曼氏隐球菌的遗传转化，以用于控制由蚊子传播的虫媒病毒。
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