Tkachenko M M, Korol P O
Bohomolets National Medical University, 01601, Kiev, T. Shevchenko Blvd, 13, Ukraine.
Bohomolets National Medical University, 01601, Kiev, T. Shevchenko Blvd, 13, UkraineKiev Clinical City Hospital 12, 01103, Kiev, Pidvysotskoho str., 4a, Ukraine.
Probl Radiac Med Radiobiol. 2017 Dec;22:476-483.
The objective of the work to determine the diagnostic role of the three phase bone scintigraphy (3 F BS) in the early prediction of paraendoprosthetic complications of the hip and knee joints of the participants in clean up workers of Chornobyl accident.
The 3 F BS method were investigated the radionuclide kinetic parameters of the inclusion and distribution of radiopharmaceuticals (RF) in damaged joints in the 75 male clean up workers.
It was established that calculating the quantitative indices of kinetics of the drug at various stages of the 3 F BS allowed to determine statistically significant differences in metabolic changes in focal lesions in articular structures. Thus, the differential diagnostic capabilities of the radionuclide method of examination of patients with arthroplasty of the hip and knee joints are elevated.
The kinetics of osteotropic RF in the foci of fixing the damaged hip and knee joints in the infectious and inflammatory processes is characterized by the predominance of retention and specific accumulation of the drug in the early static phase and the delayed static phase of the 3 F BS compared with the centers of fixation of RF in deforming osteoarthroses, which correlates with the differences in destructive reparative processes in them.
本研究旨在确定三相骨闪烁显像(3F BS)在早期预测切尔诺贝利事故清理工人髋关节和膝关节假体周围并发症中的诊断作用。
采用3F BS方法研究了75名男性清理工人受损关节中放射性药物(RF)摄取和分布的放射性核素动力学参数。
确定在3F BS的各个阶段计算药物动力学的定量指标,可以确定关节结构局灶性病变代谢变化的统计学显著差异。因此,提高了髋关节和膝关节置换术患者放射性核素检查方法的鉴别诊断能力。
在感染和炎症过程中,受损髋关节和膝关节固定灶中亲骨性RF的动力学特征是,与变形性骨关节炎中RF固定中心相比,在3F BS的早期静态期和延迟静态期,药物的滞留和特异性积聚占优势,这与它们中破坏性修复过程的差异相关。