电压门控钠离子通道：（Na ）在调节内脏痛觉中的作用。
Voltage-gated sodium channels: (Na )igating the field to determine their contribution to visceral nociception.
机构信息
Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, Australia.
Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.
出版信息
J Physiol. 2018 Mar 1;596(5):785-807. doi: 10.1113/JP273461. Epub 2018 Feb 6.
Chronic visceral pain, altered motility and bladder dysfunction are common, yet poorly managed symptoms of functional and inflammatory disorders of the gastrointestinal and urinary tracts. Recently, numerous human channelopathies of the voltage-gated sodium (Na ) channel family have been identified, which induce either painful neuropathies, an insensitivity to pain, or alterations in smooth muscle function. The identification of these disorders, in addition to the recent utilisation of genetically modified Na mice and specific Na channel modulators, has shed new light on how Na channels contribute to the function of neuronal and non-neuronal tissues within the gastrointestinal tract and bladder. Here we review the current pre-clinical and clinical evidence to reveal how the nine Na channel family members (Na 1.1-Na 1.9) contribute to abdominal visceral function in normal and disease states.
慢性内脏疼痛、运动改变和膀胱功能障碍是常见的，但对胃肠道和泌尿道功能和炎症性疾病的这些症状的管理却很差。最近，已经鉴定出许多电压门控钠 (Na ) 通道家族的人类通道病，其诱导疼痛性神经病、对疼痛不敏感或平滑肌功能改变。这些疾病的鉴定，除了最近使用基因修饰的 Na 小鼠和特定的 Na 通道调节剂，揭示了 Na 通道如何有助于胃肠道和膀胱内神经元和非神经元组织的功能。在这里，我们回顾了当前的临床前和临床证据，以揭示九种 Na 通道家族成员（Na 1.1-Na 1.9）如何在正常和疾病状态下有助于腹部内脏功能。
Zotero 插件