激活和抑制 IRE1α：Hsp47 和 BiP 的拉锯战。
Activating and Repressing IRE1α: The Hsp47 and BiP Tug of War.
机构信息
Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.
出版信息
Mol Cell. 2018 Jan 18;69(2):159-160. doi: 10.1016/j.molcel.2017.12.032.
Abstract
In this issue of Molecular Cell, Sepulveda et al. (2018) discovered an interesting role of Hsp47 in regulating the unfolded protein response (UPR) wherein Hsp47 binds to IRE1α and displaces BiP, thereby activating the IRE1α arm of the UPR pathway by a previously undetermined mechanism.
摘要
在本期的《分子细胞》中，Sepulveda 等人（2018 年）发现了 Hsp47 在调节未折叠蛋白反应（UPR）中的一个有趣作用，即 Hsp47 与 IRE1α 结合并取代 BiP，从而通过以前未确定的机制激活 UPR 途径的 IRE1α 分支。
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