木乃伊霉素：来自木乃伊菌YSP-2-79的一种新型呋喃脂肪酸的结构与生物活性

Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79.

作者信息

Kimura Tōru, Tajima Ayano, Inahashi Yuki, Iwatsuki Masato, Kasai Hiroaki, Mokudai Takayuki, Niwano Yoshimi, Shiomi Kazuro, Takahashi Yōko, Ōmura Satoshi, Nakashima Takuji

机构信息

Graduate School of Infection Control Sciences, Kitasato University.

School of Marine Biosciences, Kitasato University.

出版信息

J Gen Appl Microbiol. 2018 May 21;64(2):62-67. doi: 10.2323/jgam.2017.06.004. Epub 2018 Jan 25.

DOI:10.2323/jgam.2017.06.004

PMID:29367492

Abstract

A new antibiotic, designated mumiamicin, was isolated from the cultured broth of the rare actinomycete strain, Mumia sp. YSP-2-79, by Diaion HP-20, silica gel and ODS column chromatography, followed by HPLC purification. The chemical structure of mumiamicin was elucidated as a new furan fatty acid by nuclear magnetic resonance and mass spectrometry. Mumiamicin showed antimicrobial activity and antioxidative activity.

摘要

一种名为木乃伊霉素的新型抗生素，是从稀有放线菌菌株木乃伊菌YSP - 2 - 79的培养液中分离得到的。分离过程采用了Diaion HP - 20、硅胶和ODS柱色谱法，随后通过高效液相色谱法进行纯化。通过核磁共振和质谱分析，确定木乃伊霉素的化学结构为一种新型呋喃脂肪酸。木乃伊霉素具有抗菌活性和抗氧化活性。