胶原性胃炎与感染：仅仅是巧合吗？

Collagenous Gastritis and Infection: A Mere Coincidence?

作者信息

Vinsard Daniela G, Mejia Perez Lady Katherine, Nassar Aziza, Vazquez Roque Maria I

机构信息

Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL.

出版信息

ACG Case Rep J. 2017 May 24;4:e69. doi: 10.14309/crj.2017.69. eCollection 2017.

DOI:10.14309/crj.2017.69

PMID:29367938

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5569944/

Abstract

A 21-year-old woman presented to our clinic after 7 years of abdominal pain, diarrhea, and iron-deficiency anemia. Initial upper endoscopy revealed severe inflammation and nodularity of the gastric body and active infection. After eradication therapy, esophagogastroduodenoscopy showed gastric atrophy with nodularity resolution. Histopathology revealed scattered plasma cells, eosinophils, and collagen deposition suggestive of collagenous gastritis. can induce proinflammatory cytokines, resulting in fibroblast upregulation. Collagenous gastritis may be caused by an inflammatory response associated with type I, II, and III collagen. Although further research is warranted, we hypothesize that chronic inflammation from may lead to collagenous gastritis.

摘要

一名21岁女性在经历7年的腹痛、腹泻和缺铁性贫血后前来我们诊所就诊。初次上消化道内镜检查显示胃体严重炎症和结节形成以及活动性感染。根除治疗后，食管胃十二指肠镜检查显示胃萎缩且结节消失。组织病理学显示散在的浆细胞、嗜酸性粒细胞和胶原沉积，提示胶原性胃炎。可诱导促炎细胞因子，导致成纤维细胞上调。胶原性胃炎可能由与I型、II型和III型胶原相关的炎症反应引起。尽管有必要进一步研究，但我们推测来自……的慢性炎症可能导致胶原性胃炎。（原文中“ can induce proinflammatory cytokines”和“Although further research is warranted, we hypothesize that chronic inflammation from may lead to collagenous gastritis.”两处有缺失内容）