RNA聚合酶I的激活与休眠：独特基因的独特机制
RNA polymerase I activation and hibernation: unique mechanisms for unique genes.
作者信息
Fernández-Tornero Carlos
机构信息
a Centro de Investigaciones Biológicas - CSIC , Ramiro de Maeztu 9, 28040 Madrid , Spain.
出版信息
Transcription. 2018;9(4):248-254. doi: 10.1080/21541264.2017.1416267. Epub 2018 Jan 26.
Abstract
In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA.
摘要
在酵母中，RNA聚合酶I（Pol I）对核糖体DNA（rDNA）的转录由作用于该酶水平的独特机制调控。在诸如饥饿等应激情况下，Pol I通过二聚化进入休眠状态。当生长条件恢复时，二聚体解体以及Rrn3结合驱动酶的激活，并随后使其募集到rDNA。
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