苏格兰东北部妇科肿瘤中心阿伯丁皇家医院卵巢癌根治术后的手术结果及发病率

Surgical Outcomes and Morbidity After Radical Surgery for Ovarian Cancer in Aberdeen Royal Infirmary, the Northeast of Scotland Gynaecologic Oncology Centre.

作者信息

Kalampokas Emmanouil, Young Helena, Bednarek Antonina, Habib Mohammad, Parkin David E, Gurumurthy Mahalakshmi, Cairns Mary

机构信息

Department of Gynecologic Oncology, Aberdeen Royal Infirmary, Aberdeen, U.K.

NHS Grampian, Aberdeen, U.K.

出版信息

Anticancer Res. 2018 Feb;38(2):923-928. doi: 10.21873/anticanres.12304.

DOI:10.21873/anticanres.12304

PMID:29374722

Abstract

BACKGROUND/AIM: Ovarian cancer (OC) has a high mortality rate and usually presents late in advanced stage, which poses challenges to management. Better understanding of the disease biology and application of radical surgery (RS) to achieve no visible residual tumor, alongside with chemotherapy, may lead to longer survival amongst these patients. Our purpose was to examine the demographic characteristics, surgical morbidity and outcomes of patients undergoing RS for OC.

MATERIALS AND METHODS

A retrospective cohort study of women undertaking surgery for OC between February 2014 and September 2016 in Aberdeen Royal Infirmary.

RESULTS

A total of 121 women had surgery for OC of whom 78 (64.5%) were stage II and above. Of these, 40 (51.3%) women had primary and 38 (48.7%) had interval debulking surgery with 42 (53.8%) having radical surgery. The most common procedures that were performed as part of RS included rectosigmoid resection (n=20, 47.6%), small bowel resection (n=10, 23.8%), splenectomy (n=9, 21.4%). Morbidity outcomes included blood loss >1.5 lt. (n=14, 33.3%), hospitalization >7days (n=31, 73.8%), sepsis (n=8, 19%). There was no short-term mortality. Debulking outcomes were: no macroscopic residual disease (n=36, 85.7%), ≤10 mm disease (n=2, 4.8%), and ≥10 mm disease (n=3, 7.1%).

CONCLUSION

Our findings support the practise where RS for OC can be offered to selected patients, with good surgery outcomes and low morbidity rates.

摘要

背景/目的：卵巢癌（OC）死亡率高，通常在晚期才出现，这给治疗带来了挑战。更好地了解疾病生物学特性，并应用根治性手术（RS）以实现无可见残留肿瘤，同时结合化疗，可能会延长这些患者的生存期。我们的目的是研究接受OC根治性手术患者的人口统计学特征、手术并发症及预后情况。

材料与方法

对2014年2月至2016年9月在阿伯丁皇家医院接受OC手术的女性进行回顾性队列研究。

结果

共有121名女性接受了OC手术，其中78名（64.5%）为II期及以上。在这些患者中，40名（51.3%）女性接受了初次手术，38名（48.7%）接受了间隔减瘤手术，42名（53.8%）接受了根治性手术。作为RS一部分进行的最常见手术包括直肠乙状结肠切除术（n = 20，47.6%）、小肠切除术（n = 10，23.8%）、脾切除术（n = 9，21.4%）。并发症包括失血>1.5升（n = 14，33.3%）、住院时间>7天（n = 31，73.8%）、脓毒症（n = 8，19%）。无短期死亡病例。减瘤结果为：无肉眼可见残留病灶（n = 36，85.7%）、病灶≤10毫米（n = 2，4.8%）、病灶≥10毫米（n = 3，7.1%）。