ω-3 脂肪酸可降低乌干达 HIV 和人类疱疹病毒-8 合并感染患者的 IL-6 水平。
Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
出版信息
AIDS. 2018 Feb 20;32(4):505-512. doi: 10.1097/QAD.0000000000001722.
OBJECTIVE
Kaposi sarcoma is a HIV-associated malignancy caused by human herpesvirus-8 (HHV-8) that occurs at highest incidence in sub-Saharan Africa. Kaposi sarcoma patients often present with inflammatory symptoms associated with higher mortality.
DESIGN
We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 supplementation could reduce inflammation in HIV and HHV-8 coinfected adults. Patients with acute illness, AIDS, or advanced Kaposi sarcoma were ineligible, as were pregnant women. Participant IDs were pre-randomized, blocked by Kaposi sarcoma status, to either the omega-3 or placebo arm.
METHODS
Omega-3 participants received a 3-g pill dose daily for 12 weeks (1.8-g eicosapentaenoic acid, 1.2-mg docosapentaenoic acid); placebo participants received 44.8 mg of high oleic safflower oil that appeared indistinguishable from the active supplement. Intervention effects were evaluated as the baseline-adjusted mean difference after 12 weeks between omega-3 and placebo participants in concentrations of fatty acids, inflammatory cytokines, and immune cells.
RESULTS
The final study population included 56 Kaposi sarcoma patients and 11 Kaposi sarcoma-negative, HIV and HHV-8-positive participants randomized to receive either omega-3 (N = 33) or placebo (N = 34). Inflammatory cytokine IL-6 concentrations decreased in omega-3 participants (-0.78 pg/ml) but increased in placebo participants (+3.2 pg/ml; P = 0.04). We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08). CD8 T-cell counts tended to increase in the omega-3 arm Kaposi sarcoma patients (+60 cells/μl), in contrast to decreases (-47 cells/μl) among placebo (P = 0.11).
CONCLUSION
Omega-3 supplementation decreased IL-6 concentrations among HIV and HHV-8 coinfected Ugandans, which may have clinical benefit for Kaposi sarcoma patients.
目的
卡波氏肉瘤是一种由人类疱疹病毒 8（HHV-8）引起的 HIV 相关恶性肿瘤，在撒哈拉以南非洲的发病率最高。卡波氏肉瘤患者常出现炎症症状，死亡率较高。
设计
我们在乌干达进行了一项双盲、随机、安慰剂对照研究，以测试欧米伽 3 补充剂是否可以减少 HIV 和 HHV-8 合并感染的成年人的炎症。患有急性疾病、艾滋病或晚期卡波氏肉瘤的患者以及孕妇均不符合条件。参与者 ID 进行了预随机分组，按卡波氏肉瘤的状态分为欧米伽 3 或安慰剂组。
方法
欧米伽 3 组参与者每天服用 3 克药丸，持续 12 周（1.8 克二十碳五烯酸，1.2 毫克二十二碳六烯酸）；安慰剂组参与者服用 44.8mg 高油酸红花油，与活性补充剂外观无法区分。干预效果评估为 12 周后，欧米伽 3 和安慰剂组参与者之间的脂肪酸、炎症细胞因子和免疫细胞浓度的基线调整均值差异。
结果
最终研究人群包括 56 名卡波氏肉瘤患者和 11 名卡波氏肉瘤阴性、HIV 和 HHV-8 阳性参与者，随机分为接受欧米伽 3（N=33）或安慰剂（N=34）组。欧米伽 3 组参与者的炎症细胞因子 IL-6 浓度下降（-0.78pg/ml），而安慰剂组参与者的浓度上升（+3.2pg/ml；P=0.04）。我们观察到，在卡波氏肉瘤患者中，补充欧米伽 3 后 IL-6 下降的趋势（P=0.08）。与安慰剂组（-47 个/μl）相比，欧米伽 3 组卡波氏肉瘤患者的 CD8 T 细胞计数倾向于增加（+60 个/μl；P=0.11）。
结论
在乌干达的 HIV 和 HHV-8 合并感染人群中，欧米伽 3 补充剂降低了 IL-6 浓度，这可能对卡波氏肉瘤患者有临床益处。
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