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特发性颅内高压与减肥手术:文献综述及两例病例报告

Idiopathic intracranial hypertension and bariatric surgery: a literature review and a presentation of two cases.

作者信息

Okoroafor Francois, Karim Muhammad Ali, Ali Abdulmajid

机构信息

a Department of Surgery , University Hospital Ayr, Ayrshire and Arran , Ayr , UK.

出版信息

Br J Neurosurg. 2019 Feb;33(1):112-114. doi: 10.1080/02688697.2018.1427211. Epub 2018 Jan 31.

Abstract

OBJECTIVE

There is paucity of data concerning the impact of bariatric surgery on idiopathic intracranial hypertension (IIH). We therefore present the clinical course of two cases that were managed at our centre, which is a regional referral centre for bariatric surgery and present a literature review of patients with IIH who underwent bariatric surgery for the treatment of obesity.

METHOD

Two patients were referred for bariatric surgery who were both morbidly obese and were diagnosed with IIH. One patient underwent bariatric surgery; the other patient's weight was managed conservatively. We followed up both patients for 2 years. PubMed was searched for published studies of patients with IIH undergoing bariatric surgery.

RESULTS

The patient that underwent weight loss surgery achieved sustained weight loss from 108kg to 87kg and gross resolution of their symptoms. The patient whose weight was managed conservatively lost weight initially and then put the weight back on. Her IIH symptoms persisted despite CSF shunt therapy. The literature review identified 12 original studies, containing 51 patients. Weight loss after bariatric surgery was reported for 84% of patients and improvement or resolution of IIH symptoms was reported for 84% of patients.

CONCLUSION

In light of the literature review and our experience, bariatric surgery appears to be a potential treatment option for IIH alongside the comorbidities associated with obesity. However, more robust studies are needed.

摘要

目的

关于减肥手术对特发性颅内高压(IIH)影响的数据匮乏。因此,我们介绍在我们中心治疗的两例患者的临床过程,我们中心是一家减肥手术区域转诊中心,并对接受减肥手术治疗肥胖症的IIH患者进行文献综述。

方法

两名因病态肥胖且被诊断为IIH的患者被转诊至减肥手术科室。一名患者接受了减肥手术;另一名患者的体重采用保守方法控制。我们对两名患者均进行了2年的随访。在PubMed上搜索关于接受减肥手术的IIH患者的已发表研究。

结果

接受减肥手术的患者体重持续减轻,从108千克降至87千克,症状总体缓解。体重采用保守方法控制的患者最初体重减轻,之后又恢复到原有体重。尽管进行了脑脊液分流治疗,其IIH症状仍持续存在。文献综述确定了12项原始研究,涉及51名患者。84%的患者报告了减肥手术后体重减轻,84%的患者报告了IIH症状改善或缓解。

结论

根据文献综述和我们的经验,减肥手术似乎是治疗IIH以及肥胖相关合并症的一种潜在治疗选择。然而,需要更有力的研究。

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