微小RNA置换作为一种有前景的癌症治疗方法。
miRNA displacement as a promising approach for cancer therapy.
作者信息
Gilot David, Galibert Marie-Dominique
机构信息
CNRS UMR 6290, IGDR, 2 avenue Pr Léon Bernard 35043 Rennes, France.
Université de Rennes 1, 2 avenue Pr Léon Bernard 35043 Rennes, France.
出版信息
Mol Cell Oncol. 2017 Dec 11;5(1):e1406432. doi: 10.1080/23723556.2017.1406432. eCollection 2018.
Abstract
microRNA (miRNA) are critical post-transcriptional regulators and key players in diseases development. We demonstrated that non-canonical microRNA Responsive Elements (here MRE-16) could sequester miR-16, dampening miR-16 tumor suppressor function. We developed small oligonucleotides, masking specifically these unusual miR-16 binding sites, that restored miR-16 function. This constitutes a promising targeted approach.
摘要
微小RNA（miRNA）是关键的转录后调节因子，也是疾病发展中的关键参与者。我们证明了非经典微小RNA反应元件（此处为MRE-16）可以隔离miR-16，抑制miR-16的肿瘤抑制功能。我们开发了小寡核苷酸，特异性地掩盖这些异常的miR-16结合位点，从而恢复了miR-16的功能。这构成了一种有前景的靶向方法。
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