Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China.
Dongguan Center for Disease Control and Prevention, Dongguan, Guangdong, China.
Int J Infect Dis. 2018 Jun;71:25-29. doi: 10.1016/j.ijid.2018.01.027. Epub 2018 Feb 9.
A cross-sectional community prevalence survey was conducted to investigate the sero-epidemiological features of hepatitis B virus (HBV) infection among children aged 1-14 years in Guangdong Province in 2013, and to provide baseline data for the evaluation of HBV disease burden and the impacts of HBV control.
A total of 2765 children aged 1-14 years from 16 villages/streets of eight cities in Guangdong Province were recruited as subjects. A blood sample was obtained from each subject. A chemiluminescence microparticle immunoassay (CMIA) was used to detect hepatitis B surface antigen (HBsAg), antibody to hepatitis B surface antigen (HBsAb), and antibody to hepatitis B core antigen (HBcAb).
The prevalence rates of HBsAg, HBsAb, and HBcAb among children aged 1-14 years were 1.16%, 61.63%, and 2.35%, respectively. The prevalence of HBsAg and HBcAb increased with increasing age, and the prevalence was lowest in the 1-4 years age group (0.97% for HBsAg and 1.45% for HBcAb). In contrast, the prevalence of HBsAb decreased with increasing age; however the prevalence was also highest in the 1-4 years age group (76.48%). Eastern Guangdong had the highest prevalence of HBsAg and HBcAb, and the lowest prevalence of HBsAb. The prevalence of HBsAg was under 1% in the Pearl River Delta and western Guangdong regions. Children who had received three or more doses of vaccine had a lower prevalence of HBsAg and HBcAb and a higher prevalence of HBsAb compared to those who had received fewer than three doses of vaccine.
The prevalence of HBsAg among children aged 1-14 years in Guangdong in 2013 was 1.2%, showing a dramatic decrease compared to the 1992 provincial-level cross-sectional survey (19.9%). Children aged 1-4 years and children from the Pearl River Delta had the lowest prevalence of HBsAg positivity. High vaccination coverage among children and timely vaccination of newborns has played an important role in reducing the prevalence of HBsAg.
2013 年在广东省进行了一项横断面社区流行率调查，旨在研究乙型肝炎病毒（HBV）感染在 1-14 岁儿童中的血清流行病学特征，为评估 HBV 疾病负担和 HBV 控制效果提供基线数据。
从广东省 8 个城市的 16 个村/街道中招募了 2765 名 1-14 岁的儿童作为研究对象。从每位研究对象采集一份血样，采用化学发光微粒子免疫检测（CMIA）法检测乙型肝炎表面抗原（HBsAg）、乙型肝炎表面抗体（抗-HBs）和乙型肝炎核心抗体（抗-HBc）。
1-14 岁儿童 HBsAg、抗-HBs 和抗-HBc 的流行率分别为 1.16%、61.63%和 2.35%。HBsAg 和 HBcAb 的流行率随年龄增长而增加，在 1-4 岁年龄组中最低（HBsAg 为 0.97%，HBcAb 为 1.45%）。相反，抗-HBs 的流行率随年龄增长而降低；然而，在 1-4 岁年龄组中最高（76.48%）。粤东地区 HBsAg 和 HBcAb 的流行率最高，抗-HBs 的流行率最低。珠江三角洲和粤西地区 HBsAg 的流行率低于 1%。与接种少于 3 剂疫苗的儿童相比，接种 3 剂或以上疫苗的儿童 HBsAg 和 HBcAb 的流行率较低，抗-HBs 的流行率较高。
2013 年广东省 1-14 岁儿童 HBsAg 的流行率为 1.2%，与 1992 年省级横断面调查（19.9%）相比，呈显著下降趋势。1-4 岁儿童和珠江三角洲地区儿童的 HBsAg 阳性率最低。儿童高疫苗接种率和新生儿及时接种疫苗在降低 HBsAg 流行率方面发挥了重要作用。
