Sudo K, Yamazaki I, Masuoka M, Nakayama R
Acta Endocrinol Suppl (Copenh). 1979;229:53-66. doi: 10.1530/acta.0.092s053.
Effects of the anti-androgen TSAA-291 on the gonadotrophin secretion were studied. (1) A single subcutaneous or oral administration of TSAA-291 and its caproate induced the ovulation in the proestrous rat of which the spontaneous ovulation was blocked by the treatment with chlorpromazine. (2) A single subcutaneous administration of TSAA-291 at 2.4 mg/kg to the adult male rat induced only a slight elevation in the serum LH and FSH levels at 30 min after the administration. Successive intramuscular administrations of TSAA-291 to the adult male rat for 2 or 4 weeks resulted in significant decreases in the serum LH and FSH levels at high dose levels. A dose-dependent decrease in the serum LH level but not FSH level was observed in the orchiectomized rat. (3) Successive intramuscular administrations of TSAA-291 at high dose levels to the male rat suppressed the plasma testosterone level in the testicular venous blood and general circulation.
研究了抗雄激素TSAA-291对促性腺激素分泌的影响。(1)单次皮下或口服给予TSAA-291及其己酸盐可诱导氯丙嗪处理后自发排卵受阻的动情前期大鼠排卵。(2)对成年雄性大鼠单次皮下注射2.4 mg/kg的TSAA-291，给药后30分钟血清LH和FSH水平仅略有升高。对成年雄性大鼠连续肌肉注射TSAA-291 2或4周，在高剂量水平下血清LH和FSH水平显著降低。在去势大鼠中观察到血清LH水平呈剂量依赖性下降，但FSH水平未下降。(3)对雄性大鼠连续高剂量肌肉注射TSAA-291可抑制睾丸静脉血和全身循环中的血浆睾酮水平。
