辅酶 Q10 和维生素 E 在 1 型糖尿病患儿中的抗氧化状态。

The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes.

机构信息

Zagazig University, Faculty of Medicine, Pediatric Department, Sharkia, Egypt.

出版信息

J Pediatr (Rio J). 2019 Mar-Apr;95(2):224-230. doi: 10.1016/j.jped.2017.12.005. Epub 2018 Feb 7.

DOI:10.1016/j.jped.2017.12.005

PMID:29425798

Abstract

OBJECTIVE

The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.

METHOD

This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets.

RESULTS

Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p<0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p<0.05). The platelet redox status showed a negative correlation with the A1c % levels (r=-0.31; p=0.022) and the duration of type 1 diabetes (r=-0.35, p=0.012).

CONCLUSION

Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.

摘要

目的

本研究旨在评估 1 型糖尿病患儿血浆维生素 E 和血浆及细胞内辅酶 Q10 的抗氧化状态。

方法

本病例对照研究纳入了 72 例 1 型糖尿病患儿，并与 48 例健康儿童进行了比较，这些健康儿童在年龄、性别和种族方面相匹配。根据糖化血红蛋白（A1c%），将糖尿病患儿分为血糖控制不良组和血糖控制良好组。所有儿童均接受了详细的病史采集、临床检查以及全血细胞计数、A1c%、血浆胆固醇、甘油三酯和维生素 E 水平以及血浆、红细胞和血小板中辅酶 Q10 水平的实验室检测。

结果

与血糖控制良好组和对照组相比，血糖控制不良组患儿的血浆维生素 E、辅酶 Q10、甘油三酯、低密度脂蛋白、腰围/身高比、胆固醇水平较高，高密度脂蛋白和血小板辅酶 Q10 氧化还原状态较低（p<0.05）。血浆辅酶 Q10 与 1 型糖尿病病程、甘油三酯、胆固醇、维生素 E 和 A1c%呈正相关，与糖尿病组年龄呈负相关（p<0.05）。血小板氧化还原状态与 A1c%水平呈负相关（r=-0.31；p=0.022），与 1 型糖尿病病程呈负相关（r=-0.35，p=0.012）。