核膜破裂：小孔变大孔。
Nuclear envelope rupture: little holes, big openings.
机构信息
Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
出版信息
Curr Opin Cell Biol. 2018 Jun;52:66-72. doi: 10.1016/j.ceb.2018.02.001. Epub 2018 Feb 21.
Abstract
The nuclear envelope (NE), which is a critical barrier between the DNA and the cytosol, is capable of extensive dynamic membrane remodeling events in interphase. One of these events, interphase NE rupture and repair, can occur in both normal and disease states and results in the loss of nucleus compartmentalization. NE rupture is not lethal, but new research indicates that it could have broad impacts on genome stability and activate innate immune responses. These observations suggest a new model for how changes in NE structure could be pathogenic in cancer, laminopathies, and autoinflammatory syndromes, and redefine the functions of nucleus compartmentalization.
摘要
核膜（NE）是 DNA 和细胞质之间的关键屏障，在间期能够进行广泛的动态膜重塑事件。其中一个事件是间期核膜破裂和修复，它可以在正常和疾病状态下发生，导致核区室的丧失。核膜破裂本身并不致命，但新的研究表明，它可能对基因组稳定性产生广泛影响，并激活先天免疫反应。这些观察结果表明，核膜结构的变化如何在癌症、核纤层病和自身炎症综合征中产生致病性，以及重新定义核区室化的功能，提出了一个新的模型。
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