阴道黏膜中缺乏乳杆菌的社区状态类型中，细胞毒性蛋白阴道溶素水平较高。
Higher Levels of a Cytotoxic Protein, Vaginolysin, in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa.
出版信息
Sex Transm Dis. 2018 Apr;45(4):e14-e17. doi: 10.1097/OLQ.0000000000000774.
Abstract
Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.
摘要
阴道溶素（VLY）是阴道加德纳菌产生的一种细胞毒性蛋白，可能与细菌性阴道病有关。我们观察到，阴道加德纳菌阳性、乳杆菌水平低、阴道冲洗史、Nugent 评分高和阴道 pH 值高的女性阴道溶素水平升高。随着阴道溶素水平的升高，炎症标志物的表达并不高。阴道溶素在细菌性阴道病中的作用需要进一步评估。
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