Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Int J Mol Sci. 2018 Mar 1;19(3):700. doi: 10.3390/ijms19030700.
We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity, () expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity.
我们之前已经证明，金合欢多酚（AP）具有很强的抗肥胖、抗糖尿病和抗特应性皮炎作用。在本研究中，我们研究了 AP 的抗高血压作用。使用自发性高血压大鼠（SHR）和对照的 Wistar Kyoto 大鼠（WKY）进行研究。WKY 和 SHR 自由摄入含 AP 的食物或不含 AP 的食物（对照组）4 周，并测量其血压。AP 给药后，SHR 组的收缩压和舒张压均明显低于对照组。AP 组和对照组的 WKY 收缩压或舒张压无差异。AP 给药不改变 SHR 肾脏中的血管紧张素转换酶（ACE）活性、（）表达和超氧化物歧化酶（SOD）活性。SHR 的血液 SOD 活性在 AP 组明显高于对照组。AP 对高血压具有降压作用，但对正常血压几乎没有影响。AP 的降压作用可能与增加血液 SOD 活性的抗氧化作用有关。
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