TREM2 与淀粉样蛋白β：爱恨交织。
TREM2 and Amyloid Beta: A Love-Hate Relationship.
机构信息
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Neuron. 2018 Mar 7;97(5):991-993. doi: 10.1016/j.neuron.2018.02.018.
Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits.
TREM2 突变会增加晚发性 AD 的风险。在本期《神经元》杂志上，Zhao 等人（2018）表明 TREM2 可结合 Aβ 以增强其清除作用，而 Lee 等人（2018）则证明了在 AD 小鼠中过表达人 TREM2 可改善 Aβ 相关缺陷。
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