Malaria Immunology Section, Laboratory of Malaria and Vector Research, and.
Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland, USA.
J Clin Invest. 2018 Apr 2;128(4):1264-1266. doi: 10.1172/JCI120260. Epub 2018 Mar 12.
Malaria, caused by mosquito-transmitted Plasmodium parasites, continues to take a major toll on global health. The development of drugs and vaccines that reduce malaria transmission from humans back to mosquitos could contribute to the control and eventual eradication of malaria, but research models for the early clinical evaluation of candidate interventions are lacking. In this issue of the JCI, Collins and colleagues report the successful transmission of Plasmodium falciparum parasites from humans to mosquitoes during controlled human malaria infection, thus providing a potential tool to accelerate the development of much needed transmission-blocking drugs and vaccines.
疟疾是由蚊子传播的疟原虫引起的,它继续对全球健康造成重大影响。开发能够减少疟疾病毒从人类传播回蚊子的药物和疫苗,可能有助于控制和最终消除疟疾,但在候选干预措施的早期临床评估方面,研究模型仍存在不足。在本期 JCI 中,Collins 及其同事报告了在受控的人类疟疾感染期间成功地将恶性疟原虫从人类传播到蚊子,从而为加速开发急需的阻断传播的药物和疫苗提供了一种潜在工具。