酒精对HIV疾病发病机制、合并症及衰老的影响：整合临床前和临床研究结果
Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings.
作者信息
Molina Patricia E, Simon Liz, Amedee Angela M, Welsh David A, Ferguson Tekeda F
机构信息
Comprehensive Alcohol-HIV/AIDS Research Center and Alcohol and Drug Abuse Center of Excellence, LSUHSC, 1901 Perdido St., New Orleans, LA, USA.
出版信息
Alcohol Alcohol. 2018 Jul 1;53(4):439-447. doi: 10.1093/alcalc/agy016.
Abstract
: Effective combined antiretroviral therapy regimens have extended survival of persons living with HIV (PLWH). Heavy alcohol consumption is common in PLWH. This overview integrates evidence from clinical and preclinical research to identify salient alcohol-related mechanisms and comorbidities contributing to disease pathogenesis and accelerated aging and senescence in PLWH.
摘要
有效的联合抗逆转录病毒治疗方案延长了艾滋病毒感染者（PLWH）的生存期。大量饮酒在PLWH中很常见。本综述整合了临床和临床前研究的证据，以确定导致PLWH疾病发病机制、加速衰老和衰老的与酒精相关的显著机制和合并症。
相似文献
1
Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings.酒精对HIV疾病发病机制、合并症及衰老的影响：整合临床前和临床研究结果
Alcohol Alcohol. 2018 Jul 1;53(4):439-447. doi: 10.1093/alcalc/agy016.
2
The New Orleans Alcohol Use in HIV Study: Launching a Translational Investigation of the Interaction of Alcohol Use with Biological and Socioenvironmental Risk Factors for Multimorbidity in People Living with HIV.新奥尔良艾滋病毒酒精使用研究：启动一项关于艾滋病毒感染者中酒精使用与生物和社会环境风险因素对多种疾病交互作用的转化研究。
Alcohol Clin Exp Res. 2019 Apr;43(4):704-709. doi: 10.1111/acer.13980. Epub 2019 Mar 10.
3
Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions.酒精使用与人类免疫缺陷病毒（HIV）感染：当前认知、影响及未来方向
Alcohol Clin Exp Res. 2016 Oct;40(10):2056-2072. doi: 10.1111/acer.13204. Epub 2016 Sep 22.
4
Alcohol and associated characteristics among older persons living with human immunodeficiency virus on antiretroviral therapy.接受抗逆转录病毒治疗的老年艾滋病毒感染者的饮酒情况及相关特征。
Subst Abus. 2014;35(3):245-53. doi: 10.1080/08897077.2014.890997.
5
Psychosocial stressors and alcohol use, severity, and treatment receipt across human immunodeficiency virus (HIV) status in a nationally representative sample of US residents.在一个具有全国代表性的美国居民样本中，研究了人类免疫缺陷病毒（HIV）感染者的心理社会压力源与饮酒、严重程度和治疗接受情况之间的关系。
Subst Abus. 2017 Jul-Sep;38(3):269-277. doi: 10.1080/08897077.2016.1268238. Epub 2016 Dec 7.
6
Lifetime Alcohol Use Trajectories and Health Status Among Persons Living with HIV (PLWH).终身饮酒轨迹与 HIV 感染者（PLWH）的健康状况。
J Stud Alcohol Drugs. 2022 Sep;83(5):695-703. doi: 10.15288/jsad.21-00303.
7
HIV/AIDS, comorbidity, and alcohol: can we make a difference?艾滋病毒/艾滋病、合并症与酒精：我们能有所作为吗？
Alcohol Res Health. 2010;33(3):258-66.
8
Association between alcohol consumption trajectories and clinical profiles among women and men living with HIV.感染艾滋病毒的男性和女性饮酒轨迹与临床特征之间的关联。
Am J Drug Alcohol Abuse. 2018;44(1):85-94. doi: 10.1080/00952990.2017.1335317. Epub 2017 Jun 16.
9
"Moving Forward with Life": Acceptability of a Brief Alcohol Reduction Intervention for People Receiving Antiretroviral Therapy in South Africa."向前生活"：南非接受抗逆转录病毒疗法的人群对简短酒精减少干预措施的可接受性。
Int J Environ Res Public Health. 2020 Aug 7;17(16):5706. doi: 10.3390/ijerph17165706.
10
Alcohol Screening and Brief Intervention for Persons Living with HIV.针对艾滋病毒感染者的酒精筛查与简短干预
J Assoc Nurses AIDS Care. 2017 Mar-Apr;28(2):266-278. doi: 10.1016/j.jana.2016.09.003. Epub 2016 Sep 17.
引用本文的文献
1
Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.艾滋病毒感染老年人群中的酒精使用及其与身体虚弱、骨折和跌倒的关联。
Alcohol Res. 2025 Aug 8;45(1):08. doi: 10.35946/arcr.v45.1.08. eCollection 2025.
2
Chronic binge alcohol dysregulates omental adipose tissue extracellular matrix in simian immunodeficiency virus-infected macaques.慢性暴饮酒精会使感染猿猴免疫缺陷病毒的猕猴的网膜脂肪组织细胞外基质失调。
Alcohol Clin Exp Res (Hoboken). 2025 Apr;49(4):741-753. doi: 10.1111/acer.70012. Epub 2025 Feb 20.
3
Impact of alcohol use disorder on antiretroviral therapy adherence in adults with HIV/AIDS at University of Gondar, Northwest Ethiopia.在埃塞俄比亚贡德尔大学，酒精使用障碍对 HIV/AIDS 成人抗逆转录病毒治疗依从性的影响。
Sci Rep. 2024 Nov 29;14(1):29745. doi: 10.1038/s41598-024-79406-y.
4
Pain prospectively predicts alcohol use disorder among people living with HIV: A commentary on Palfai et al. (2024).疼痛前瞻性地预测了艾滋病毒感染者中的酒精使用障碍：对帕尔法伊等人（2024年）的评论。
Alcohol Clin Exp Res (Hoboken). 2025 Jan;49(1):102-105. doi: 10.1111/acer.15499. Epub 2024 Nov 20.
5
High fat, high sucrose diet promotes increased expression of ACE2 receptor in the SIV-infected host: implications for SARS-CoV-2 infection.高脂肪、高蔗糖饮食会促进SIV感染宿主中ACE2受体表达增加：对SARS-CoV-2感染的启示。
Front Nutr. 2024 Sep 30;11:1458106. doi: 10.3389/fnut.2024.1458106. eCollection 2024.
6
Reasons for not seeking alcohol treatment among a sample of Florida adults with HIV who perceived the need for treatment.在佛罗里达州一群认为有治疗需求的 HIV 成年患者中，那些没有寻求酒精治疗的原因。
Addict Sci Clin Pract. 2024 Oct 4;19(1):71. doi: 10.1186/s13722-024-00491-5.
7
Chronic binge alcohol mediated hepatic metabolic adaptations in SIV-infected female rhesus macaques.慢性 binge 酒精介导的 SIV 感染雌性恒河猴肝脏代谢适应。
Alcohol Alcohol. 2024 Jul 21;59(5). doi: 10.1093/alcalc/agae060.
8
Alcohol Impairs Bioenergetics and Differentiation Capacity of Myoblasts from Simian Immunodeficiency Virus-Infected Female Macaques.酒精损害感染猴免疫缺陷病毒雌性食蟹猴肌母细胞的生物能量和分化能力。
Int J Mol Sci. 2024 Feb 19;25(4):2448. doi: 10.3390/ijms25042448.
9
Promoting HIV care continuum outcomes among people who use drugs and alcohol: a systematic review of randomized trials evaluating behavioral HIV care interventions published from 2011 to 2023.促进药物和酒精使用者的艾滋病护理连续体结局：对 2011 年至 2023 年发表的评估行为性艾滋病护理干预的随机试验的系统评价。
BMC Public Health. 2023 Nov 7;23(1):2182. doi: 10.1186/s12889-023-17113-5.
10
Prevalence and characteristics of metabolic syndrome and its components among adults living with and without HIV in Nigeria: a single-center study.在尼日利亚，患有和未患有 HIV 的成年人中代谢综合征及其成分的流行率和特征：一项单中心研究。
BMC Endocr Disord. 2023 Jul 28;23(1):160. doi: 10.1186/s12902-023-01419-x.
本文引用的文献
1
Alcohol Use and HIV Disease Progression in an Antiretroviral Naive Cohort.抗逆转录病毒治疗初治队列中饮酒与 HIV 疾病进展的关系。
J Acquir Immune Defic Syndr. 2018 Apr 15;77(5):492-501. doi: 10.1097/QAI.0000000000001624.
2
A miRNA Signature for Cognitive Deficits and Alcohol Use Disorder in Persons Living with HIV/AIDS.一种针对感染艾滋病毒/艾滋病患者认知缺陷和酒精使用障碍的微小RNA特征
Front Mol Neurosci. 2017 Nov 15;10:385. doi: 10.3389/fnmol.2017.00385. eCollection 2017.
3
Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications.酒精性肌病：病理生理机制与临床意义
Alcohol Res. 2017;38(2):207-217.
4
Cellular and molecular mechanisms of alcohol-induced osteopenia.酒精性骨质减少的细胞和分子机制。
Cell Mol Life Sci. 2017 Dec;74(24):4443-4453. doi: 10.1007/s00018-017-2585-y. Epub 2017 Jul 3.
5
Hazardous alcohol consumption is not associated with CD4+ T-cell count decline among PLHIV in Kampala Uganda: A prospective cohort study.在乌干达坎帕拉，危险饮酒与艾滋病毒感染者的CD4+ T细胞计数下降无关：一项前瞻性队列研究。
PLoS One. 2017 Jun 30;12(6):e0180015. doi: 10.1371/journal.pone.0180015. eCollection 2017.
6
Decreased myoblast differentiation in chronic binge alcohol-administered simian immunodeficiency virus-infected male macaques: role of decreased miR-206.慢性暴饮酒精的猿猴免疫缺陷病毒感染雄性猕猴中肌成纤维细胞分化减少：miR-206减少的作用
Am J Physiol Regul Integr Comp Physiol. 2017 Sep 1;313(3):R240-R250. doi: 10.1152/ajpregu.00146.2017. Epub 2017 Jun 21.
7
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis.酒精性心肌病的病因：线粒体、氧化应激与细胞凋亡。
Int J Biochem Cell Biol. 2017 Aug;89:125-135. doi: 10.1016/j.biocel.2017.06.009. Epub 2017 Jun 9.
8
Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae.酒精相关的肠道菌群失调会损害肺部对肺炎克雷伯菌的宿主防御能力。
PLoS Pathog. 2017 Jun 12;13(6):e1006426. doi: 10.1371/journal.ppat.1006426. eCollection 2017 Jun.
9
Geriatric syndromes: new frontiers in HIV and sarcopenia.老年综合征：HIV与肌肉减少症的新前沿
AIDS. 2017 Jun 1;31 Suppl 2(Suppl 2):S137-S146. doi: 10.1097/QAD.0000000000001444.
10
Lifetime and recent alcohol use and bone mineral density in adults with HIV infection and substance dependence.感染HIV且有物质依赖的成年人的终生及近期饮酒情况与骨密度
Medicine (Baltimore). 2017 Apr;96(17):e6759. doi: 10.1097/MD.0000000000006759.
Zotero 插件