Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, 1200, Brussels, Belgium.
IREC Imaging Platform (2IP), Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200, Brussels, Belgium.
Nutr Diabetes. 2018 Mar 7;8(1):15. doi: 10.1038/s41387-018-0019-z.
Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders.
The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet.
Bifidogenic effect of WBE was evidenced by an induction of both Bifidobacterium animalis and Bifidobacterium pseudolongum in the caecal content. WBE supplementation normalised WD-induced fat-mass expansion, steatosis, hypercholesterolemia, hyperleptinemia, hyperglycemia and hyperinsulinemia reaching the values of control mice. The reduced glucose-dependent insulinotropic polypeptide (GIP) release observed in WD + WBE mice may be a protective mechanism in terms of reducing adipose tissue storage, hepatic steatosis and glucose homoeostasis.
We found that WBE completely abolished WD-induced metabolic disorders. Those results might be useful to take into account nutritional advices to treat obesity and related metabolic disorders such as type 2 diabetes, hypercholesterolaemia and fatty liver diseases when obesity was already established.
谷物中存在的不可消化碳水化合物，如低聚果糖和阿拉伯木聚糖，是预防肥胖和相关代谢紊乱的有前途的益生元营养素。
本研究旨在确定小麦麸衍生的阿拉伯木聚糖低聚糖对喂食西式饮食（WD）的肥胖小鼠的纠正作用。WD 喂养 4 周后，用小麦麸提取物（WBE）补充剂（5%）再喂养 4 周，而对照组则接受标准饮食。
WBE 的双歧杆菌促生作用通过诱导盲肠内容物中双歧杆菌和假长双歧杆菌的生长得到证明。WBE 补充剂使 WD 诱导的脂肪量增加、脂肪变性、高胆固醇血症、高瘦素血症、高血糖和高胰岛素血症正常化，达到对照组小鼠的水平。在 WD+WBE 小鼠中观察到的葡萄糖依赖性胰岛素释放肽（GIP）释放减少可能是一种保护机制，可以减少脂肪组织储存、肝脂肪变性和葡萄糖稳态。
我们发现 WBE 完全消除了 WD 诱导的代谢紊乱。这些结果可能有助于在肥胖已经存在的情况下，考虑营养建议来治疗肥胖和相关的代谢紊乱，如 2 型糖尿病、高胆固醇血症和脂肪肝疾病。
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