Service of Nephrology, Department of Specialties, University Hospital of Geneva, Switzerland; Division of Chronic Diseases, Institute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Switzerland.
Service of Nephrology, University Hospital of Lausanne, Switzerland.
Mayo Clin Proc. 2018 May;93(5):586-596. doi: 10.1016/j.mayocp.2017.12.010. Epub 2018 Mar 15.
To assess the influence of caffeine on arterial stiffness by exploring the association of urinary excretion of caffeine and its related metabolites with pulse pressure (PP) and pulse wave velocity (PWV).
Families were randomly selected from the general population of 3 Swiss cities from November 25, 2009, through April 4, 2013. Pulse pressure was defined as the difference between the systolic and diastolic blood pressures obtained by 24-hour ambulatory monitoring. Carotid-femoral PWV was determined by applanation tonometry. Urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured in 24-hour urine collections. Multivariate linear and logistic mixed models were used to explore the associations of quartiles of urinary caffeine and metabolite excretions with PP, high PP, and PWV.
We included 863 participants with a mean ± SD age of 47.1±17.6 years, 24-hour PP of 41.9±9.2 mm Hg, and PWV of 8.0±2.3 m/s. Mean (SE) brachial PP decreased from 43.5 (0.5) to 40.5 (0.6) mm Hg from the lowest to the highest quartiles of 24-hour urinary caffeine excretion (P<.001). The odds ratio (95% CI) of high PP decreased linearly from 1.0 to 0.52 (0.31-0.89), 0.38 (0.22-0.65), and 0.31 (0.18-0.55) from the lowest to the highest quartile of 24-hour urinary caffeine excretion (P<.001). Mean (SE) PWV in the highest caffeine excretion quartile was significantly lower than in the lowest quartile (7.8 [0.1] vs 8.1 [0.1] m/s; P=.03). Similar associations were found for paraxanthine and theophylline, whereas no associations were found with theobromine.
Urinary caffeine, paraxanthine, and theophylline excretions were associated with decreased parameters of arterial stiffness, suggesting a protective effect of caffeine intake beyond its blood pressure-lowering effect.
通过探讨尿中咖啡因及其相关代谢物的排泄与脉压（PP）和脉搏波速度（PWV）的关系，评估咖啡因对动脉僵硬的影响。
2009 年 11 月 25 日至 2013 年 4 月 4 日，从瑞士 3 个城市的普通人群中随机抽取家庭。通过 24 小时动态血压监测，定义脉压为收缩压与舒张压之差。通过平板张力测定法测定颈股 PWV。通过 24 小时尿液收集测量尿中咖啡因、黄嘌呤、茶碱和可可碱的排泄量。采用多元线性和逻辑混合模型，探讨尿中咖啡因和代谢物排泄的四分位数与 PP、高 PP 和 PWV 的关系。
我们纳入了 863 名平均年龄为 47.1±17.6 岁的参与者，24 小时 PP 为 41.9±9.2mmHg，PWV 为 8.0±2.3m/s。（SE）从最低到最高四分位数，尿中咖啡因排泄量（P<.001），肱动脉 PP 从 43.5（0.5）mmHg 降低到 40.5（0.6）mmHg。高 PP 的比值比（95%CI）从 1.0 降低到 0.52（0.31-0.89）、0.38（0.22-0.65）和 0.31（0.18-0.55），从最低到最高四分位数，尿中咖啡因排泄量（P<.001）。最高咖啡因排泄量四分位数的平均（SE）PWV 明显低于最低四分位数（7.8[0.1]vs8.1[0.1]m/s；P=.03）。黄嘌呤和茶碱也有类似的相关性，但可可碱没有相关性。
尿中咖啡因、黄嘌呤和茶碱的排泄与动脉僵硬参数的降低有关，提示咖啡因摄入的保护作用超出了其降压作用。
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