原发性肺型小细胞卵巢癌：一例报告。
Primary small cell ovarian cancer of pulmonary type: A case report.
作者信息
Kalampokas Emmanouil, Sharma Vijay, Gagliardi Tanja, Payne Fiona, Gurumurthy Mahalakshmi
机构信息
Department of Gynecologic Oncology, Ward 315, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, United Kingdom.
Department of Pathology, Royal Liverpool and Broadgreen University Hospitals, United Kingdom.
出版信息
Gynecol Oncol Rep. 2018 Feb 8;24:10-13. doi: 10.1016/j.gore.2018.02.003. eCollection 2018 May.
BACKGROUND
Primary small cell ovarian cancer of pulmonary type (SCCOPT) is a rare aggressive ovarian tumour with an incidence of <1%, usually occurring in perimenopausal or postmenopausal women and known to have a poor prognosis. Current treatment is platinum based but has not resulted in long term survival.
CASE PRESENTATION
We report a case of a 77-year old Caucasian woman who presented initially with a one-week history of abdominal discomfort with raised inflammatory markers and Ca125 of 50 μ/ml. Calcium levels were normal. She underwent primary debulking surgery, and histology showed a tumour comprising areas of classical small-cell carcinoma morphology. 6 cycles of adjuvant chemotherapy with carboplatin was offered. Relapsed/progressive disease was noted after 3 months of chemotherapy and patient died 7 months after treatment completion.
CONCLUSIONS
SCCOPT is a rare aggressive malignancy with majority of the women having an overall survival of 2 years. There is no clear consensus for the diagnosis and optimal treatment.
背景
原发性肺型小细胞卵巢癌（SCCOPT）是一种罕见的侵袭性卵巢肿瘤，发病率<1%，通常发生在围绝经期或绝经后女性，预后较差。目前的治疗以铂类为基础，但尚未实现长期生存。
病例报告
我们报告一例77岁的白种女性，最初表现为腹部不适一周，炎症标志物升高，Ca125为50μ/ml。血钙水平正常。她接受了初次肿瘤细胞减灭术，组织学显示肿瘤包含经典小细胞癌形态区域。给予6周期卡铂辅助化疗。化疗3个月后出现复发/疾病进展，患者在治疗结束7个月后死亡。
结论
SCCOPT是一种罕见的侵袭性恶性肿瘤，大多数女性的总生存期为2年。对于其诊断和最佳治疗尚无明确共识。
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