β1和β3整合素在乳腺癌、前列腺癌和胰腺癌中的新意义。
β1 and β3 integrins in breast, prostate and pancreatic cancer: A novel implication.
作者信息
Pan Boju, Guo Junchao, Liao Quan, Zhao Yupei
机构信息
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.
出版信息
Oncol Lett. 2018 Apr;15(4):5412-5416. doi: 10.3892/ol.2018.8076. Epub 2018 Feb 16.
Abstract
Integrins are transmembrane glycoproteins that consist of an α and a β subunit. Specific integrin heterodimers preferentially bind to distinct extracellular matrix (ECM) proteins to affect the characteristics of cells or the components of the ECM. Among the different integrins, β1 and β3 integrins serve essential roles in the progression of different cancer-associated processes, including the initiation, proliferation, survival, migration and invasion. Furthermore, previous studies have revealed a ratio between these two integrins in cancer cells, which also demonstrated that the functions of these two integrins are paradoxical. This indicated that the proliferation and metastasis of cancer cells are not always parallel and may be considered independently maintained. Additionally, the present review may assist in understanding certain aspects of cancer, and in making clinical decisions in a novel and more comprehensive manner.
摘要
整合素是由α和β亚基组成的跨膜糖蛋白。特定的整合素异二聚体优先结合不同的细胞外基质（ECM）蛋白，以影响细胞的特性或ECM的成分。在不同的整合素中，β1和β3整合素在不同的癌症相关过程（包括起始、增殖、存活、迁移和侵袭）的进展中发挥着重要作用。此外，先前的研究揭示了癌细胞中这两种整合素之间的比例，这也表明这两种整合素的功能是相互矛盾的。这表明癌细胞的增殖和转移并不总是平行的，可能被认为是独立维持的。此外，本综述可能有助于理解癌症的某些方面，并以新颖、更全面的方式做出临床决策。
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本文引用的文献
1
Cilengitide combined with cetuximab and platinum-based chemotherapy as first-line treatment in advanced non-small-cell lung cancer (NSCLC) patients: results of an open-label, randomized, controlled phase II study (CERTO).西利单抗联合西妥昔单抗和铂类化疗作为晚期非小细胞肺癌（NSCLC）患者的一线治疗：一项开放标签、随机、对照的 II 期研究（CERTO）的结果。
Ann Oncol. 2015 Aug;26(8):1734-40. doi: 10.1093/annonc/mdv219. Epub 2015 May 4.
2
Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion.延伸因子2激酶调节TG2/β1整合素/Src/尿激酶型纤溶酶原激活物受体途径以及介导胰腺癌细胞侵袭的上皮-间质转化。
J Cell Mol Med. 2014 Nov;18(11):2235-51. doi: 10.1111/jcmm.12361. Epub 2014 Sep 12.
3
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Genet Mol Res. 2014 Aug 25;13(3):6455-65. doi: 10.4238/2014.August.25.9.
4
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5
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Nature. 2014 Jul 17;511(7509):298-9. doi: 10.1038/nature13506. Epub 2014 Jun 25.
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9
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Sci Signal. 2014 Feb 11;7(312):ra15. doi: 10.1126/scisignal.2004751.
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