Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Korea.
Department of Pharmaceutical Engineering, Cheongju University, Cheongju 28503, Korea.
Int J Mol Sci. 2018 Mar 19;19(3):903. doi: 10.3390/ijms19030903.
Hydroquinone (HQ, 1,4-benzenediol) is a hydroxylated benzene metabolite with various biological activities, including anti-oxidative, neuroprotective, immunomodulatory, and anti-inflammatory functions. However, the anti-cancer activity of HQ is not well understood. In this study, the in vitro and in vivo anti-cancer activity of HQ was investigated in various cancer cells and tumor-bearing mouse models. HQ significantly induced the death of A431, SYF, B16F10, and MDA-MB-231 cells and also showed a synergistic effect on A431 cell death with other anti-cancer agents, such as adenosine-2',3'-dialdehyde and buthionine sulfoximine. In addition, HQ suppressed angiogenesis in fertilized chicken embryos. Moreover, HQ prevented lung metastasis of melanoma cells in mice in a dose-dependent manner without toxicity and adverse effects. HQ (10 mg/kg) also suppressed the generation of colon and reduced the thickness of colon tissues in azoxymethane/dextran sodium sulfate-injected mice. This study strongly suggests that HQ possesses in vitro and in vivo anti-cancer activity and provides evidence that HQ could be developed as an effective and safe anti-cancer drug.
对苯二酚（HQ，1,4-苯二酚）是一种羟基化的苯代谢物，具有多种生物学活性，包括抗氧化、神经保护、免疫调节和抗炎作用。然而，HQ 的抗癌活性尚未得到很好的理解。在这项研究中，研究了 HQ 在各种癌细胞和荷瘤小鼠模型中的体外和体内抗癌活性。HQ 显著诱导 A431、SYF、B16F10 和 MDA-MB-231 细胞死亡，并且与其他抗癌剂（如腺苷-2',3'-二醛和丁硫氨酸亚砜）对 A431 细胞死亡具有协同作用。此外，HQ 抑制了受精鸡胚中的血管生成。此外，HQ 以剂量依赖性方式防止了小鼠黑色素瘤细胞的肺转移，且没有毒性和不良反应。HQ（10mg/kg）还抑制了结肠的生成，并减少了氧化偶氮甲烷/葡聚糖硫酸钠注射小鼠的结肠组织厚度。这项研究强烈表明 HQ 具有体外和体内抗癌活性，并提供了 HQ 可开发为有效和安全的抗癌药物的证据。
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