基于人群的胸腰椎肌肉密度和大小的年龄和性别差异的研究：弗雷明汉研究。
Population-based study of age- and sex-related differences in muscle density and size in thoracic and lumbar spine: the Framingham study.
机构信息
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Orthopedic Surgery, Harvard Medical School, Harvard University, Boston, MA, USA.
出版信息
Osteoporos Int. 2018 Jul;29(7):1569-1580. doi: 10.1007/s00198-018-4490-0. Epub 2018 Mar 22.
UNLABELLED
Relative age-related deficit in trunk muscle density was greater in women than men whereas the relative decrease in muscle mass with age was similar in both sexes. The greater muscle fat content and greater age-related fat accumulation among women may contribute to women suffering more functional disabilities than men.
INTRODUCTION
A better understanding of the effect of aging on trunk musculature will have implications for physical function, disability, pain, and risk of injury in older adults. Thus, we determined the age- and sex-related differences in muscle density and size of both thoracic and lumbar trunk muscles.
METHODS
In this cross-sectional study, muscle density and size were measured from quantitative computed tomography (QCT) scans for 10 trunk muscle groups at different vertebral levels in 250 community-based men and women aged 40 to 90 years from the Framingham Offspring and Third Generation cohorts.
RESULTS
Trunk muscles in men were 20-67% larger and had 5-68% higher density than in women. The relative age-related deficits in muscle size were similar in both sexes, and decreased on average by ~ 8% per decade in both sexes. In contrast, women had greater age-related decreases in muscle density than men (- 17% in women, and - 11% in men, p < 0.01). Age-related declines varied by specific muscle, tending to be greater for outer trunk muscles than for paraspinal muscles, but within a given muscle the age-related changes in muscle density and size were similar among spinal levels.
CONCLUSION
This comprehensive study of trunk muscle deficits with increasing age may have important implications for physical function, disability, pain, and risk of injury in older adults. The greater levels of mobility impairments with aging in women may in part be explained by greater proportion of intramuscular fat tissue and greater age-related fat accumulation in trunk muscles in women than in men.
未加标签
与男性相比，女性躯干肌肉密度的相对年龄相关缺陷更大，而肌肉质量随年龄的相对下降在两性中相似。女性肌肉脂肪含量较高，且与年龄相关的脂肪堆积较多，这可能导致女性比男性更容易出现功能障碍。
引言
更好地了解衰老对躯干肌肉的影响将对老年人的身体功能、残疾、疼痛和受伤风险产生影响。因此，我们确定了男女躯干肌肉密度和大小的年龄和性别相关差异。
方法
在这项横断面研究中，我们从定量 CT（QCT）扫描中测量了 250 名来自弗雷明汉后代和第三代队列的 40 至 90 岁社区男性和女性的 10 个躯干肌肉群在不同椎体水平的肌肉密度和大小。
结果
男性躯干肌肉比女性大 20-67%，密度高 5-68%。男女两性的肌肉大小与年龄相关的相对缺陷相似，两性平均每十年减少约 8%。相比之下，女性的肌肉密度与年龄相关的下降幅度大于男性（女性下降 17%，男性下降 11%，p<0.01）。年龄相关的下降情况因特定肌肉而异，通常外躯干肌肉比椎旁肌肉的下降幅度更大，但在给定的肌肉中，肌肉密度和大小随脊柱水平的年龄相关变化相似。
结论
这项关于随年龄增长的躯干肌肉缺陷的综合研究可能对老年人的身体功能、残疾、疼痛和受伤风险有重要影响。女性随年龄增长的活动能力下降幅度较大，部分原因可能是女性躯干肌肉中肌肉内脂肪组织的比例较高，以及与年龄相关的脂肪堆积较多。
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