用于慢性肾病即时监测的微型化生物和化学传感器。
Miniaturized Bio-and Chemical-Sensors for Point-of-Care Monitoring of Chronic Kidney Diseases.
机构信息
Nanotechnolgy Research Laboratory, Research School of Engineering, Australian National University, Canberra ACT 0200, Australia.
Department of Engineering, University of Messina, I-9866 Messina, Italy.
出版信息
Sensors (Basel). 2018 Mar 22;18(4):942. doi: 10.3390/s18040942.
This review reports the latest achievements in point-of-care (POC) sensor technologies for the monitoring of ammonia, creatinine and urea in patients suffering of chronic kidney diseases (CKDs). Abnormal levels of these nitrogen biomarkers are found in the physiological fluids, such as blood, urine and sweat, of CKD patients. Delocalized at-home monitoring of CKD biomarkers via integration of miniaturized, portable, and low cost chemical- and bio-sensors in POC devices, is an emerging approach to improve patients' health monitoring and life quality. The successful monitoring of CKD biomarkers, performed on the different body fluids by means of sensors having strict requirements in term of size, cost, large-scale production capacity, response time and simple operation procedures for use in POC devices, is reported and discussed.
本综述报告了即时检测（POC）传感器技术在监测慢性肾病（CKD）患者氨、肌酐和尿素方面的最新进展。这些氮生物标志物的异常水平存在于 CKD 患者的生理体液中，如血液、尿液和汗液。通过将小型化、便携式和低成本的化学和生物传感器集成到 POC 设备中，实现 CKD 生物标志物的分散式居家监测，是一种改善患者健康监测和生活质量的新兴方法。本研究报告并讨论了通过在不同体液中使用传感器对 CKD 生物标志物进行成功监测的情况，这些传感器在尺寸、成本、大规模生产能力、响应时间和 POC 设备使用操作程序简单性方面有严格要求。
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