青少年自身免疫性甲状腺炎中浸润甲状腺的细胞。
Cells infiltrating the thyroid in juvenile autoimmune thyroiditis.
作者信息
Kontiainen S, Lautenschlager I, Nyberg M, Mäenpää J
出版信息
Clin Exp Immunol. 1987 Jan;67(1):89-94.
Cell samples derived from the thyroid glands of twelve children with juvenile autoimmune thyroiditis (JAIT) were analysed. The cytological findings were those of chronic lymphocytic thyroiditis in eight and suggestive of that disease in four patients. About 86% of the cells infiltrating the thyroid were lymphocytes, 4% were lymphoid blasts, 6% neutrophils and 3% monocytes. Analysis using monoclonal antibodies showed that about 60% of the lymphocytes were T cells and half of the lymphocytes expressed HLA Class II-antigens. T helper cells dominated with a T helper/suppressor ratio of 2.2 in thyroid while the ratio was 1.2 in peripheral blood. Of the thyroid epithelial cells, 80% also expressed HLA class II. The immune activation and immunoglobulin synthesis within the thyroid are discussed.
对来自12名青少年自身免疫性甲状腺炎（JAIT）患儿甲状腺的细胞样本进行了分析。细胞学检查结果显示，8例为慢性淋巴细胞性甲状腺炎，4例提示为该病。浸润甲状腺的细胞中约86%为淋巴细胞，4%为淋巴母细胞，6%为中性粒细胞，3%为单核细胞。使用单克隆抗体分析表明，约60%的淋巴细胞为T细胞，且一半的淋巴细胞表达HLA II类抗原。甲状腺中以辅助性T细胞为主，辅助性T细胞/抑制性T细胞比例为2.2，而外周血中的比例为1.2。80%的甲状腺上皮细胞也表达HLA II类抗原。文中讨论了甲状腺内的免疫激活和免疫球蛋白合成。
Zotero 插件