无症状儿童的睑板腺变化的意义。

The significance of meibomian gland changes in asymptomatic children.

机构信息

School of Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

出版信息

Ocul Surf. 2018 Jul;16(3):301-305. doi: 10.1016/j.jtos.2018.03.006. Epub 2018 Mar 21.

DOI:10.1016/j.jtos.2018.03.006

PMID:29574281

Abstract

PURPOSE

To evaluate meibomian gland morphology and function in children without ocular discomfort.

METHOD

A total of 266 eyes of 266 children without signs or symptoms of ocular surface dysfunction were enrolled. Morphology of meibomian glands (MG) and non-invasive break-up time (BUT) was assessed by noncontact meibography. Based on lipid layer thickness (LLT) of the tear film measurements, 66 children were chosen to be assessed by meibomian glands yielding liquid secretion (MGYLS).

RESULTS

Based on the presence of physiologic conjunctival follicles (PCF), participants were divided into normal or PCF groups. The distortion and deficiency of MG function was significantly higher in PCF group (P = 0.002, 0.007, respectively). Five different gland duct shapes (vertical, tortuous, overriding, hooked, U-shaped) were observed. MG deficiency was positively correlated with age (R = 0.362, P < 0.001). Distortion and the number of MG showed no correlation with age (P > 0.05). However, distortion and deficiency of MG were negatively correlated with LLT (P < 0.001, P < 0.01).

CONCLUSION

Children with PCF had significantly more MG distortion and deficiency which was associated with LLT. These results prompt future studies to determine if changes in MG morphology are congenital or acquired.

摘要

目的

评估无眼部不适儿童的睑板腺形态和功能。

方法

共纳入 266 名无眼表面功能障碍迹象或症状的儿童的 266 只眼。通过非接触式睑板腺照相术评估睑板腺（MG）形态和非侵入性泪膜破裂时间（BUT）。根据泪膜脂质层厚度（LLT）的测量结果，选择 66 名儿童进行睑板腺液体分泌（MGYLS）评估。

结果

根据生理性结膜滤泡（PCF）的存在，将参与者分为正常组或 PCF 组。PCF 组的 MG 功能扭曲和缺失明显更高（P=0.002，0.007）。观察到五种不同的腺管形状（垂直、迂曲、重叠、钩状、U 形）。MG 缺乏与年龄呈正相关（R=0.362，P<0.001）。MG 扭曲和数量与年龄无相关性（P>0.05）。然而，MG 的扭曲和缺失与 LLT 呈负相关（P<0.001，P<0.01）。