血浆血管生成素样蛋白 4 与糖尿病和非糖尿病患者的磷脂转移蛋白活性相关：低度炎症增强的作用。
Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation.
机构信息
Department of Endocrinology, University of Groningen and University Medical Center, P.O. Box 301, 9700 RB, Groningen, The Netherlands.
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
出版信息
Lipids Health Dis. 2018 Mar 27;17(1):60. doi: 10.1186/s12944-018-0717-5.
BACKGROUND
Angiopoietin-like 4 (ANGPTL4) inhibits lipoprotein lipase, whereas phospholipid transfer protein (PLTP) enhances hepatic triglyceride secretion. Both factors may be upregulated by inflammatory pathways. Since the extent to which these circulating factors are interrelated is unknown, we determined the relationship between plasma ANGPTL4 and PLTP activity, and assessed whether such a relationship could be explained by high sensitivity C-reactive protein (hsCRP) levels as a marker of low-grade chronic inflammation.
METHODS
Fasting plasma ANGPTL4, PLTP activity (liposome-vesicle high density lipoprotein system) and hsCRP were measured in 41 type 2 diabetic (T2DM) subjects and 36 non-diabetic subjects.
RESULTS
Plasma ANGPTL4 and PLTP activity were increased in T2DM (p < 0.001 for each), coinciding with elevated hsCRP, triglycerides and non-esterified fatty acids (NEFA) (p = 0.031 to 0.001). In univariate analysis, ANGTLP4 was correlated with PLTP activity (Rs = 0.309, p = 0.006), whereas both factors were related to hsCRP and NEFA levels (Rs = 0.304 to 0.411, p < 0.01 to < 0.001). In multivariable linear regression analysis adjusting for age, sex, glucose, total cholesterol, triglycerides and NEFA, ANGPTL4 and PLTP activity each remained positively associated with hsCRP (β = 0.315, p = 0.003 and β = 0.299, p = 0.034, respectively). Plasma ANGPTL4 remained positively associated with PLTP activity when taking account of age, sex, glucose, total cholesterol, triglycerides and NEFA (β = 0.315, p = 0.003). Notably, this association disappeared after further adjustment for hsCRP (β = 0.131, p = 0.25).
CONCLUSIONS
In conclusion, plasma ANGPTL4 and PLTP activity are interrelated, which may at least in part be explained by low-grade chronic inflammation. A pro-inflammatory state could affect triglyceride metabolism via concerted effects on ANGPTL4 and PLTP.
背景
血管生成素样蛋白 4（ANGPTL4）抑制脂蛋白脂肪酶，而磷脂转移蛋白（PLTP）则增强肝甘油三酯的分泌。这两个因素都可能受到炎症途径的上调。由于这些循环因子之间相互关联的程度尚不清楚，因此我们确定了血浆 ANGPTL4 与 PLTP 活性之间的关系，并评估了这种关系是否可以用作为低度慢性炎症标志物的高敏 C 反应蛋白（hsCRP）水平来解释。
方法
在 41 例 2 型糖尿病（T2DM）患者和 36 例非糖尿病患者中测量空腹血浆 ANGPTL4、PLTP 活性（脂蛋白囊泡高密度脂蛋白系统）和 hsCRP。
结果
T2DM 患者的血浆 ANGPTL4 和 PLTP 活性均升高（每项均 p<0.001），同时 hsCRP、甘油三酯和非酯化脂肪酸（NEFA）也升高（p=0.031 至 0.001）。在单变量分析中，ANGPTLP4 与 PLTP 活性相关（Rs=0.309，p=0.006），而这两个因素均与 hsCRP 和 NEFA 水平相关（Rs=0.304 至 0.411，p<0.01 至<0.001）。在调整年龄、性别、血糖、总胆固醇、甘油三酯和 NEFA 后进行多变量线性回归分析，ANGPTL4 和 PLTP 活性均与 hsCRP 呈正相关（β=0.315，p=0.003 和β=0.299，p=0.034）。考虑到年龄、性别、血糖、总胆固醇、甘油三酯和 NEFA 后，血浆 ANGPTL4 与 PLTP 活性仍呈正相关（β=0.315，p=0.003）。值得注意的是，这种关联在进一步调整 hsCRP 后消失（β=0.131，p=0.25）。
结论
总之，血浆 ANGPTL4 和 PLTP 活性相互关联，这至少部分可以用低度慢性炎症来解释。炎症状态可能通过对 ANGPTL4 和 PLTP 的协同作用影响甘油三酯代谢。
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