降低接受放疗的胶质母细胞瘤患者神经症状的干预措施：从理论到临床实践

Interventions to Reduce Neurological Symptoms in Patients with GBM Receiving Radiotherapy: From Theory to Clinical Practice.

作者信息

Palombi Lucia, Marchetti Paolo, Salvati Maurizio, Osti Mattia Falchetto, Frati Luigi, Frati Alessandro

机构信息

Department of Neurological Sciences-Neurosurgery, Faculty of Medicine, La Sapienza University of Rome, Rome, Italy

Department of Oncology, Faculty of Medicine and Psychology, La Sapienza University of Rome, Rome, Italy.

出版信息

Anticancer Res. 2018 Apr;38(4):2423-2427. doi: 10.21873/anticanres.12494.

DOI:10.21873/anticanres.12494

PMID:29599372

Abstract

BACKGROUND

Patients affected by glioblastoma often develop cerebral oedema as a life-threatening complication. Although there is no approved pharmacological intervention, such cerebral oedema is usually treated with dexamethasone. Dexamethasone has been shown in experimental studies to reduce cerebral oedema with only few mineralocorticoid side-effects. The goal of our study was to examine its efficacy in reducing the emergence of neurological deficits during the Stupp protocol.

PATIENTS AND METHODS

We studied a retrospective cohort of 459 patients, assigned in controlled groups: in group A, patients received radiochemotherapy followed by adjuvant chemotherapy; in group B, patients received an equivalent combined treatment with dexamethasone.

RESULTS

The frequency of neurological symptoms was significantly lower in dexamethasone-treated patients.

CONCLUSION

Early diagnosis and prevention of cerebral oedema are important because functional consequences can be anticipated with an appropriate medical treatment. Thus, our study reveals that dexamethasone acts to prevent the appearance of neurological symptoms in patients with brain tumour.

摘要