Serotonergic Modulation of Olfaction in Rodents and Insects.

Recent advances in genetic tools and optical imaging technology have allowed rodent and researchers to explore the relationship between serotonergic modulation and olfactory processing at a mechanistic level previously unfeasible. Here, I review the basic organization of olfactory and serotonergic systems in both rodents and and draw comparisons where similarities exist. I discuss circuit level models that explain many of serotonin's effects on olfactory responses in the olfactory system's inputs and outputs. Finally, I discuss models of integration within wide-field centrifugal neurons to emphasize the importance of studying serotonergic neurons directly to build more realistic models of olfactory and modulatory interactions.