蛋白质液-液相分离：细胞生物学的一个新领域。
Protein Phase Separation: A New Phase in Cell Biology.
机构信息
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; KU Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
出版信息
Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27.
Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, formation, regulation, and function of membraneless organelles. A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
细胞区室和细胞器组织生物物质。大多数著名的细胞器都通过膜边界与周围环境隔开。还有许多所谓的无膜细胞器，最近的研究表明，这些细胞器是蛋白质和 RNA 分子的超分子组装体，通过蛋白质相分离形成。最近的发现揭示了无膜细胞器的分子特性、形成、调节和功能。细胞生物学、生物物理学、物理化学、结构生物学和生物信息学的一系列技术开始帮助建立一个新兴领域的分子原理，从而为令人兴奋的发现铺平了道路，包括治疗与年龄相关疾病的新疗法。
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