March of Dimes Prematurity Research Center at Stanford University, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
March of Dimes Prematurity Research Center at Stanford University, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Environ Res. 2018 Jul;164:546-555. doi: 10.1016/j.envres.2018.03.020. Epub 2018 Mar 31.
We investigated risks of preeclampsia phenotypes from potential residential pesticide exposures, including 543 individual chemicals and 69 physicochemical groupings that were applied in the San Joaquin Valley of California during the study period, 1998-2011. The study population was derived from birth certificate data linked with Office of Statewide Health Planning and Development maternal and infant hospital discharge data. The following numbers of women with preeclampsia phenotypes were identified: 1045 with superimposed (pre-existing hypertension with preeclampsia) preeclampsia (265 with gestational weeks 20-31 and 780 with gestational weeks 32-36); 3471 with severe preeclampsia (824 with gestational weeks 20-31 and 2647 with gestational weeks 32-36); and 2780 with mild preeclampsia (207 with gestational weeks 20-31 and 2573 with gestational weeks 32-36). The reference population for these groups was 197,461 women who did not have diabetes (gestational or pre-existing), did not have any hypertensive disorder, and who delivered at 37 weeks or later. The frequency of any exposure was lower or about the same in each preeclampsia case group (further delineated by gestational age), and month time period, relative to the frequency in reference population controls. Nearly all odds ratios were below 1.0 for these any vs no exposure comparisons. This study showed a general lack of increased risks between a range of agriculture pesticide exposures near women's residences and various preeclampsia phenotypes.
我们研究了潜在的住宅农药暴露对先兆子痫表型的风险，包括在研究期间（1998-2011 年）加利福尼亚州圣华金谷使用的 543 种单个化学物质和 69 种物理化学分组。研究人群来自出生证明数据，与州卫生规划和发展办公室母婴医院出院数据相关联。确定了以下具有先兆子痫表型的妇女数量：1045 例并发（先兆子痫伴先前存在的高血压）先兆子痫（265 例妊娠 20-31 周，780 例妊娠 32-36 周）；3471 例严重先兆子痫（824 例妊娠 20-31 周，2647 例妊娠 32-36 周）；2780 例轻度先兆子痫（207 例妊娠 20-31 周，2573 例妊娠 32-36 周）。这些组别的参考人群是 197461 名没有糖尿病（妊娠或先前存在）、没有任何高血压疾病且在 37 周或以后分娩的妇女。在每个先兆子痫病例组（按妊娠年龄进一步细分）和月份期间，任何暴露的频率都低于或与参考人群对照的频率相同。对于这些任何 vs 无暴露比较，几乎所有的比值比都低于 1.0。这项研究表明，在妇女住所附近的一系列农业农药暴露与各种先兆子痫表型之间普遍缺乏增加的风险。
