University of Pennsylvania, Vaxconsult, 4650 Wismer Rd., Doylestown, PA 18902, United States.
UAB School of Medicine, CHB 114, 1600 7th Avenue South, Birmingham, AL 35233, United States.
Vaccine. 2019 Nov 28;37(50):7437-7442. doi: 10.1016/j.vaccine.2018.02.089. Epub 2018 Apr 3.
The human cytomegalovirus (HCMV) is the most important infectious cause of congenital abnormalities and also of infectious complications of transplantation. The biology of the infection is complex and acquired immunity does not always prevent reinfection. Nevertheless, vaccine development is far advanced, with numerous candidate vaccines being tested, both live and inactivated. This article summarizes the status of the candidate vaccines.
人巨细胞病毒（HCMV）是导致先天性畸形的最重要传染性病原体，也是移植术后感染性并发症的主要原因。该感染的生物学特性十分复杂，获得性免疫并不能完全预防再感染。尽管如此，疫苗的研发仍已取得较大进展，多种候选疫苗正在进行临床试验，包括活疫苗和灭活疫苗。本文对候选疫苗的研究现状进行了综述。
