Samardžić Mira, Popović Nataša, Terzić Nataša, Popović-Samardžić Milena, Nedović-Vuković Mirjana
Srp Arh Celok Lek. 2016 Jul-Aug;144(7-8):408-12.
The incidence rate of childhood type1 diabetes continues to rise across Europe by an average of approximately 3–4% per annum.
The aim of this study was to examine incidence and trends of type 1 diabetes in children aged 0–14 years in Montenegro from 1997 to 2011.
This was a prospective study. Primary case ascertainment was from a diabetes register, and a secondary independent data source was from hospital notifications. Case ascertainment was 100% complete using the capture-recapture method. Standardized incidence rates were calculated and trends estimated using the Poisson regression.
A total of 298 children (157 boys and 141 girls) were diagnosed with type 1 diabetes before 15 years of age during 1997–2011. The mean age-standardized incidence was 15.0/100,000 persons (95% CI: 12.3–17.6) during this period, increasing from 11.7/100,000 in 1997 to 18.8/100,000 in 2011. The agespecific rates per 100,000 persons per year were 10.7, 17.2, and 18.2 at ages 0–4 years, 5–9 years, and 10–14 years, respectively. A significant linear trend in incidence (p = 0.002) has been observed over time, with an average annual increase of 4.2%. The increase in incidence was present in both genders, with the largest relative increase in the 0–4 years age group for boys (11.0%; p = 0.006).
The incidence of type 1 diabetes in Montenegro children continues to increase. We need further monitoring and additional research in order to explain the cause.
在欧洲,儿童1型糖尿病的发病率持续上升,平均每年约增长3% - 4%。
本研究旨在调查1997年至2011年期间黑山共和国0至14岁儿童1型糖尿病的发病率及发病趋势。
这是一项前瞻性研究。主要病例确诊来自糖尿病登记册,二级独立数据源来自医院报告。采用捕获 - 再捕获法,病例确诊率达100%。计算标准化发病率,并使用泊松回归估计发病趋势。
1997年至2011年期间,共有298名儿童(157名男孩和141名女孩)在15岁前被诊断为1型糖尿病。在此期间,年龄标准化发病率的平均值为15.0/100,000人(95%置信区间:12.3 - 17.6),从1997年的11.7/100,000上升至2011年的18.8/100,000。0至4岁、5至9岁和10至14岁年龄组每年每100,000人的年龄别发病率分别为10.7、17.2和18.2。随时间观察到发病率有显著的线性趋势(p = 0.002),平均每年增长4.2%。发病率的上升在男女两性中均有体现,男孩在0至4岁年龄组的相对增幅最大(11.0%;p = 0.006)。
黑山共和国儿童1型糖尿病的发病率持续上升。我们需要进一步监测并开展更多研究以解释其病因。